DegronMD

Uniprot ID: O75603

Source protein: Chorion-specific transcription factor GCMb

Source gene: GCM2

Class: DEG_SPOP_SBC_1

Location: 382:386

E3 ligase: SPOP

DEGRON score: 0.7442

ASA_SCORE: 64.38

COIL: 0.608

CONS_SCORE: 0.4825

DSS_SCORE: 0.3512

HELIX: 0.0174

FCONS_SCORE: 1.0172

RIG_SCORE: 0.8461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S390Y	TCGA-A5-A0GW	UCEC	TCGA	VITTT	DEG_SPOP_SBC_1	0.2222
p.S390Y	DO41103	UCEC	ICGC	VITTT	DEG_SPOP_SBC_1	0.2222
p.V382M	TCGA-AR-A0TQ	BRCA	TCGA	VITTT	DEG_SPOP_SBC_1	0.7208
p.V382M	DO1623	BRCA	ICGC	VITTT	DEG_SPOP_SBC_1	0.7208
p.T381I	TCGA-EE-A2GC	SKCM	TCGA	VITTT	DEG_SPOP_SBC_1	0.3056
p.T381I	DO218906	SKCA	ICGC	VITTT	DEG_SPOP_SBC_1	0.3056
p.T381I	DO37839	SKCM	ICGC	VITTT	DEG_SPOP_SBC_1	0.3056
p.T386I	DO233109	GACA	ICGC	VITTT	DEG_SPOP_SBC_1	0.7078
p.P372L	DO220907	MELA	ICGC	VITTT	DEG_SPOP_SBC_1	0.0556
p.P396F	DO222843	MELA	ICGC	VITTT	DEG_SPOP_SBC_1	0.0556
p.T384A	SIDM01090	Colorectal Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.7139
p.T384A	ACH-000943	Colon/Colorectal Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	0.7139
p.T384A	RKO	large_intestine	COSMIC	VITTT	DEG_SPOP_SBC_1	0.7139
p.P377L	SIDM00578	Neuroblastoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.1944
p.P377L	ACH-000804	Neuroblastoma	CCLE	VITTT	DEG_SPOP_SBC_1	0.1944
p.P377L	NB1	autonomic_ganglia	COSMIC	VITTT	DEG_SPOP_SBC_1	0.1944
p.A378T	SIDM01609	Endometrial Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75603	Chorion-specific transcription factor GCMb	DEG_SPOP_SBC_1	382:386	VITTT	SPOP	0.7442	More...
P17275	Transcription factor JunB	DEG_SPOP_SBC_1	98:102	VITTT	SPOP	0.9993	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5155:5159	VITTT	SPOP	0.9393	More...
Q9H334	Forkhead box protein P1	DEG_SPOP_SBC_1	423:427	VITTT	SPOP	0.9878	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	302:306	VITTT	SPOP	0.7	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons