DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 5155:5159

E3 ligase: SPOP

DEGRON score: 0.9393

ASA_SCORE: 86.98

COIL: 0.8314

CONS_SCORE: 0

DSS_SCORE: 0.656

HELIX: 0.0138

FCONS_SCORE: 0

RIG_SCORE: 0.7669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P5148H	TCGA-BA-4078	HNSC	TCGA	VITTT	DEG_SPOP_SBC_1	0.1389
p.P5148H	DO14173	HNSC	ICGC	VITTT	DEG_SPOP_SBC_1	0.1389
p.K5149E	TCGA-BR-6452	STAD	TCGA	VITTT	DEG_SPOP_SBC_1	0.2778
p.K5149E	DO38404	STAD	ICGC	VITTT	DEG_SPOP_SBC_1	0.2778
p.G5161E	TCGA-QB-AA9O	SKCM	TCGA	VITTT	DEG_SPOP_SBC_1	0.2778
p.G5161E	DO220874	MELA	ICGC	VITTT	DEG_SPOP_SBC_1	0.2778
p.G5161E	DO51267	SKCM	ICGC	VITTT	DEG_SPOP_SBC_1	0.2778
p.T5147K	DO228971	LICA	ICGC	VITTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75603	Chorion-specific transcription factor GCMb	DEG_SPOP_SBC_1	382:386	VITTT	SPOP	0.7442	More...
P17275	Transcription factor JunB	DEG_SPOP_SBC_1	98:102	VITTT	SPOP	0.9993	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5155:5159	VITTT	SPOP	0.9393	More...
Q9H334	Forkhead box protein P1	DEG_SPOP_SBC_1	423:427	VITTT	SPOP	0.9878	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	302:306	VITTT	SPOP	0.7	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons