DegronMD - P17275(JUNB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A191P	TCGA-AG-3584	READ	TCGA	PPVY	ITCH	179:182	Mutation rewiring degron network	0.0833
p.A191P	DO37173	READ	ICGC	PPVY	ITCH	179:182	Mutation rewiring degron network	0.0833
p.P93T	TCGA-R5-A7ZI	STAD	TCGA	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1944
p.P93T	DO222342	STAD	ICGC	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1944
p.G235D	DO230346	COCA	ICGC	EEPQTVPEA	DEG_COP1_1	241:249	Mutation rewiring degron network	0.1667
p.G171C	DO222794	COCA	ICGC	PPVY	ITCH	179:182	Mutation rewiring degron network	0.1111
p.P243S	DO233885	GACA	ICGC	EEPQTVPEA	DEG_COP1_1	241:249	Mutation altering degron motif	0.5641
p.L185I	DO233882	GACA	ICGC	PPVY	ITCH	179:182	Mutation rewiring degron network	0.25
p.T238N	DO228974	LICA	ICGC	EEPQTVPEA	DEG_COP1_1	241:249	Mutation blocking phosphorylation signal	0.6944
p.Q108H	DO27827	MALY	ICGC	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.1667
p.S187R	DO52686	MALY	ICGC	PPVY	ITCH	179:182	Mutation rewiring degron network	0.1944
p.T238I	DO52675	MALY	ICGC	EEPQTVPEA	DEG_COP1_1	241:249	Mutation blocking phosphorylation signal	0.6944
p.P176S	DO222753	MELA	ICGC	PPVY	ITCH	179:182	Mutation rewiring degron network	0.25
p.E177K	DO37703	SKCM	ICGC	PPVY	ITCH	179:182	Mutation rewiring degron network	0.2778
p.D253E	DO229248	THCA	ICGC	EEPQTVPEA	DEG_COP1_1	241:249	Mutation rewiring degron network	0.2222
p.D253E	ACH-000848	Liver Cancer	CCLE	EEPQTVPEA	DEG_COP1_1	241:249	Mutation rewiring degron network	0.2222
p.V181I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPVY	ITCH	179:182	Mutation altering degron motif	0.5965
p.V181I	ACH-002062	Lymphoma	CCLE	PPVY	ITCH	179:182	Mutation altering degron motif	0.5965
p.N96S	SIDM00094	Kidney Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.N96S	ACH-002199	Kidney Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.N96S	SN12C	kidney	COSMIC	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2778
p.P103H	SIDM00487	Colorectal Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.P103H	ACH-000963	Colon/Colorectal Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.P103H	CCK-81	large intestine	COSMIC	VITTT	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.3056
p.Y109H	SIDM00228	Thyroid Gland Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	98:102	Mutation blocking phosphorylation signal	0.5833
p.Y109H	ACH-000897	Thyroid Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	98:102	Mutation blocking phosphorylation signal	0.5833
p.D253N	ACH-000643	Breast Cancer	CCLE	EEPQTVPEA	DEG_COP1_1	241:249	Mutation rewiring degron network	0.2222
p.G231D	ACH-001839	Bile Duct Cancer	CCLE	EEPQTVPEA	DEG_COP1_1	241:249	Mutation rewiring degron network	0.0556
p.R250S	ACH-002380	Non-Cancerous	CCLE	EEPQTVPEA	DEG_COP1_1	241:249	Mutation rewiring degron network	0.3056

Kaplan plot for JUNB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JUNB

UniProt ID: P17275

Entrez ID: 3726

Protein name: Transcription factor JunB (Transcription factor AP-1 subunit JunB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JUNB in