DegronMD

Uniprot ID: P17275

Source protein: Transcription factor JunB

Source gene: JUNB

Class: DEG_COP1_1

Location: 241:249

E3 ligase: COP1

DEGRON score: 0.9991

ASA_SCORE: 104.5778

COIL: 0.8639

CONS_SCORE: 0.579

DSS_SCORE: 0.7331

HELIX: 0.1199

FCONS_SCORE: 1.3976

RIG_SCORE: 0.6632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G235D	DO230346	COCA	ICGC	EEPQTVPEA	DEG_COP1_1	0.1667
p.P243S	DO233885	GACA	ICGC	EEPQTVPEA	DEG_COP1_1	0.5641
p.T238N	DO228974	LICA	ICGC	EEPQTVPEA	DEG_COP1_1	0.6944
p.T238I	DO52675	MALY	ICGC	EEPQTVPEA	DEG_COP1_1	0.6944
p.D253E	DO229248	THCA	ICGC	EEPQTVPEA	DEG_COP1_1	0.2222
p.D253E	ACH-000848	Liver Cancer	CCLE	EEPQTVPEA	DEG_COP1_1	0.2222
p.D253N	ACH-000643	Breast Cancer	CCLE	EEPQTVPEA	DEG_COP1_1	0.2222
p.G231D	ACH-001839	Bile Duct Cancer	CCLE	EEPQTVPEA	DEG_COP1_1	0.0556
p.R250S	ACH-002380	Non-Cancerous	CCLE	EEPQTVPEA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17275	Transcription factor JunB	DEG_COP1_1	241:249	EEPQTVPEA	COP1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons