DegronMD

Uniprot ID: P17275

Source protein: Transcription factor JunB

Source gene: JUNB

Class: DEG_SPOP_SBC_1

Location: 98:102

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 72.12

COIL: 0.8276

CONS_SCORE: 0.4465

DSS_SCORE: 0.5429

HELIX: 0.0106

FCONS_SCORE: 0.8941

RIG_SCORE: 0.7426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P93T	TCGA-R5-A7ZI	STAD	TCGA	VITTT	DEG_SPOP_SBC_1	0.1944
p.P93T	DO222342	STAD	ICGC	VITTT	DEG_SPOP_SBC_1	0.1944
p.Q108H	DO27827	MALY	ICGC	VITTT	DEG_SPOP_SBC_1	0.1667
p.N96S	SIDM00094	Kidney Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.2778
p.N96S	ACH-002199	Kidney Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	0.2778
p.N96S	SN12C	kidney	COSMIC	VITTT	DEG_SPOP_SBC_1	0.2778
p.P103H	SIDM00487	Colorectal Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.3056
p.P103H	ACH-000963	Colon/Colorectal Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	0.3056
p.P103H	CCK-81	large_intestine	COSMIC	VITTT	DEG_SPOP_SBC_1	0.3056
p.Y109H	SIDM00228	Thyroid Gland Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.5833
p.Y109H	ACH-000897	Thyroid Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75603	Chorion-specific transcription factor GCMb	DEG_SPOP_SBC_1	382:386	VITTT	SPOP	0.7442	More...
P17275	Transcription factor JunB	DEG_SPOP_SBC_1	98:102	VITTT	SPOP	0.9993	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5155:5159	VITTT	SPOP	0.9393	More...
Q9H334	Forkhead box protein P1	DEG_SPOP_SBC_1	423:427	VITTT	SPOP	0.9878	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	302:306	VITTT	SPOP	0.7	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons