DegronMD

Uniprot ID: Q9H334

Source protein: Forkhead box protein P1

Source gene: FOXP1

Class: DEG_SPOP_SBC_1

Location: 423:427

E3 ligase: SPOP

DEGRON score: 0.9878

ASA_SCORE: 79

COIL: 0.8492

CONS_SCORE: 0.5203

DSS_SCORE: 0.5606

HELIX: 0.0862

FCONS_SCORE: 0.9674

RIG_SCORE: 0.7466

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R425Q	NCI-SNU-1	stomach	COSMIC	VITTT	DEG_SPOP_SBC_1	0.7329
p.T426I	DO41638	UCEC	ICGC	VITTT	DEG_SPOP_SBC_1	0.7078
p.V425F	TCGA-86-7713	LUAD	TCGA	VITTT	DEG_SPOP_SBC_1	0.7068
p.V423F	DO24712	LUAD	ICGC	VITTT	DEG_SPOP_SBC_1	0.7068
p.S424P	SK-UT-1	soft_tissue	COSMIC	VITTT	DEG_SPOP_SBC_1	0.6752
p.T428I	TCGA-AJ-A3BH	UCEC	TCGA	VITTT	DEG_SPOP_SBC_1	0.3056
p.G422C	TCGA-AP-A051	UCEC	TCGA	VITTT	DEG_SPOP_SBC_1	0.3056
p.S422P	SIDM01113	Other Sarcomas	GDSC	VITTT	DEG_SPOP_SBC_1	0.3056
p.S422P	ACH-000939	Sarcoma	CCLE	VITTT	DEG_SPOP_SBC_1	0.3056
p.S422P	SK-UT-1	soft_tissue	COSMIC	VITTT	DEG_SPOP_SBC_1	0.3056
p.M429I	DO229389	BTCA	ICGC	VITTT	DEG_SPOP_SBC_1	0.2778
p.M429I	SIDM02013	Colorectal Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.2778
p.G420C	DO42673	UCEC	ICGC	VITTT	DEG_SPOP_SBC_1	0.25
p.W418C	NCI-H1573	lung	COSMIC	VITTT	DEG_SPOP_SBC_1	0.1944
p.G433E	DO52048	HNSC	ICGC	VITTT	DEG_SPOP_SBC_1	0.1667
p.G435E	TCGA-CN-A6V1	HNSC	TCGA	VITTT	DEG_SPOP_SBC_1	0.1111
p.A414T	TCGA-AX-A1CE	UCEC	TCGA	VITTT	DEG_SPOP_SBC_1	0.0833
p.A414T	TCGA-BR-4280	STAD	TCGA	VITTT	DEG_SPOP_SBC_1	0.0833
p.A414V	TCGA-MA-AA41	CESC	TCGA	VITTT	DEG_SPOP_SBC_1	0.0833
p.R436C	DO223732	CESC	ICGC	VITTT	DEG_SPOP_SBC_1	0.0833
p.R436C	DO50078	UCEC	ICGC	VITTT	DEG_SPOP_SBC_1	0.0833
p.R414H	SNU-407	large_intestine	COSMIC	VITTT	DEG_SPOP_SBC_1	0.0833
p.R437M	DO51759	STAD	ICGC	VITTT	DEG_SPOP_SBC_1	0.0556

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75603	Chorion-specific transcription factor GCMb	DEG_SPOP_SBC_1	382:386	VITTT	SPOP	0.7442	More...
Q9H334	Forkhead box protein P1	DEG_SPOP_SBC_1	423:427	VITTT	SPOP	0.9878	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	302:306	VITTT	SPOP	0.7	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5155:5159	VITTT	SPOP	0.9393	More...
P17275	Transcription factor JunB	DEG_SPOP_SBC_1	98:102	VITTT	SPOP	0.9993	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons