DegronMD

Uniprot ID: Q9H0E3

Source protein: Histone deacetylase complex subunit SAP130

Source gene: SAP130

Class: DEG_SPOP_SBC_1

Location: 422:426

E3 ligase: SPOP

DEGRON score: 0.8621

ASA_SCORE: 89.5

COIL: 0.941

CONS_SCORE: 0.4819

DSS_SCORE: 0.4701

HELIX: 0.02

FCONS_SCORE: 1.062

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R418W	DO48444	BLCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.2222
p.R418W	ACH-000432	Leukemia	CCLE	AVTTS	DEG_SPOP_SBC_1	0.2222
p.R418W	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.2222
p.E426K	DO10475	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7022
p.A425D	DO228948	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7793
p.A425D	DO228971	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7793
p.A425V	DO222494	MELA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.6936
p.D422N	ACH-000985	Colon/Colorectal Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	0.6932
p.D422N	LS-411N	large_intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons