DegronMD - Q8TEW8(PARD3B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y610F	TCGA-18-3417	LUSC	TCGA	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1667
p.G235V	TCGA-85-8355	LUSC	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.G235V	DO45488	LUSC	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.R1012C	TCGA-A5-A0G2	UCEC	TCGA	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.2778
p.P1039H	TCGA-A5-A1OF	UCEC	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.2778
p.F248V	TCGA-A6-5665	COAD	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7068
p.F248V	DO9756	COAD	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7068
p.R1046G	TCGA-AA-3527	COAD	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation altering degron motif	0.7568
p.E250K	TCGA-AA-A022	COAD	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7022
p.E250K	TCGA-BF-AAP2	SKCM	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7022
p.E250K	TCGA-EE-A3AE	SKCM	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7022
p.E250K	DO10647	COAD	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7022
p.E250K	DO234383	ESAD	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7022
p.E250K	DO37802	SKCM	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7022
p.E250K	DO219466	SKCM	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7022
p.R1040W	TCGA-AF-3911	READ	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.3056
p.R1040W	TCGA-B5-A11E	UCEC	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.3056
p.N1007D	TCGA-AJ-A8CW	UCEC	TCGA	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation blocking phosphorylation signal	0.5833
p.S613G	TCGA-CG-4442	STAD	TCGA	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.P1031S	TCGA-D3-A8GQ	SKCM	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation substituting flanking lysine	0.1667
p.P1049S	TCGA-D6-6516	HNSC	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.25
p.R244W	TCGA-DU-6392	LGG	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.R244W	DO22237	LGG	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.R244W	SIDM00572	Gastric Carcinoma	GDSC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.R244W	SIDM00927	Small Cell Lung Carcinoma	GDSC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.R244W	ACH-000871	Lung Cancer	CCLE	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.R244W	ACH-000911	Gastric Cancer	CCLE	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.R244W	NUGC-3	stomach	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.R244W	NCI-H510A	lung	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.8634
p.P1031L	TCGA-EE-A2M6	SKCM	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation substituting flanking lysine	0.1667
p.P1056H	TCGA-EY-A215	UCEC	TCGA	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation blocking phosphorylation signal	0.5
p.S613C	TCGA-JY-A93E	ESCA	TCGA	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N259S	TCGA-YD-A9TA	SKCM	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.N259S	DO219503	SKCM	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.E1039K	DO224618	BRCA	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.2778
p.E1039K	DO1016	BRCA	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.2778
p.A1013V	DO8224	COAD	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.3056
p.A1013V	DO43065	UCEC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.3056
p.T1019M	DO230347	COCA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation altering degron motif	0.7423
p.T1019M	DO51255	SKCM	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation altering degron motif	0.7423
p.R622Q	DO222769	COCA	ICGC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2778
p.S606F	DO219918	DLBC	ICGC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.0556
p.E1032A	DO10842	ESAD	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.0833
p.L1010P	DO233232	GACA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.2222
p.E1048K	DO233272	GACA	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.2778
p.R1025C	DO233212	GACA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1667
p.K1005N	DO228976	LICA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation substituting flanking lysine	0.1944
p.C253F	DO229041	LICA	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.25
p.N259D	DO45185	LIRI	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.D1047Y	DO218942	LUAD	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.3056
p.E1055V	DO24100	LUAD	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.0833
p.Q1027L	DO230524	LUSC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1111
p.N1004K	DO52346	LUSC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.0556
p.N1004K	DO229201	THCA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.0556
p.R1017H	DO228437	MALY	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation altering degron motif	0.7133
p.E245K	DO222521	MELA	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.591
p.S240I	DO232761	PBCA	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.P1009T	DO37419	SKCM	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1944
p.P1009L	DO37419	SKCM	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1944
p.P1053S	DO37410	SKCM	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.1389
p.P1042A	DO40918	UCEC	ICGC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation altering degron motif	0.6392
p.R1017C	DO41331	UCEC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation altering degron motif	0.719
p.K1028T	SIDM02074	Esophageal Carcinoma	GDSC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation substituting flanking lysine	0.1944
p.N623D	SIDM01057	Acute Myeloid Leukemia	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00401	Melanoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM01248	Thyroid Gland Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00919	Ovarian Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00945	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM01078	Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00230	Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM01247	Burkitt's Lymphoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00871	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM00872	Breast Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM01167	Thyroid Gland Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM01564	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.N623D	SIDM01699	Chondrosarcoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.E1032D	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.0833
p.E1032D	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.0833
p.D624E	SIDM00705	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.D624E	SIDM00696	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.D624E	ACH-002369	Non-Cancerous	CCLE	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.D624E	ACH-002383	Non-Cancerous	CCLE	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.P608S	SIDM00789	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1111
p.P608S	ACH-000997	Colon/Colorectal Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1111
p.P608S	HCT-15	large intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1111
p.G235C	SIDM00238	Ovarian Carcinoma	GDSC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.G235C	ACH-000947	Ovarian Cancer	CCLE	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.G235C	OVK-18	ovary	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0833
p.T619N	SIDM00203	Ewing's Sarcoma	GDSC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7055
p.T619N	ACH-002111	Bone Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7055
p.T619N	EW-11	bone	COSMIC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7055
p.D1024G	SIDM00251	Gastric Carcinoma	GDSC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1944
p.D1024G	TGBC11TKB	stomach	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1944
p.G1016S	SIDM01228	Melanoma	GDSC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation altering degron motif	0.6993
p.G1016S	CHL-1	skin	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation altering degron motif	0.6993
p.Y1056C	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation blocking phosphorylation signal	0.5
p.Y1056C	Farage	haematopoietic and lymphoid tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation blocking phosphorylation signal	0.5
p.G1008R	ACH-001566	Skin Cancer	CCLE	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1667
p.R1033Q	ACH-001737	Leukemia	CCLE	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation blocking phosphorylation signal	0.5556
p.R1033Q	ACH-002222	Leukemia	CCLE	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation blocking phosphorylation signal	0.5556
p.R1033Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation blocking phosphorylation signal	0.5556
p.G1008W	ACH-002061	Leukemia	CCLE	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1667
p.Q625K	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.N1056K	NCI-H250	lung	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation blocking phosphorylation signal	0.5
p.G1036R	NCI-H524	lung	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.1944
p.N1024K	NCI-H250	lung	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1944
p.H612Y	RD	soft tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.A257V	LS-411N	large intestine	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.1389
p.Q613K	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.P1045L	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation altering degron motif	0.7582
p.G1004R	NCI-H524	lung	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.0556
p.R1040Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation rewiring degron network	0.3056
p.A1028T	GP5d	large intestine	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation substituting flanking lysine	0.1944
p.R1027H	NCI-SNU-5	stomach	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.1111
p.G1043R	NCI-H524	lung	COSMIC	FPLYED	LIG_APCC_ABBA_1	1041:1046	Mutation altering degron motif	0.7568
p.P1010L	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	1014:1019	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PARD3B

UniProt ID: Q8TEW8

Entrez ID: 117583

Protein name: Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PARD3B in