DegronMD

Uniprot ID: Q8TEW8

Source protein: Partitioning defective 3 homolog B

Source gene: PARD3B

Class: LIG_APCC_ABBA_1

Location: 1041:1046

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9912

ASA_SCORE: 99.2

COIL: 0.8372

CONS_SCORE: 0.2746

DSS_SCORE: 0.5003

HELIX: 0.1358

FCONS_SCORE: 0.7356

RIG_SCORE: 0.7728

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1039H	TCGA-A5-A1OF	UCEC	TCGA	FPLYED	LIG_APCC_ABBA_1	0.2778
p.R1046G	TCGA-AA-3527	COAD	TCGA	FPLYED	LIG_APCC_ABBA_1	0.7568
p.R1040W	TCGA-AF-3911	READ	TCGA	FPLYED	LIG_APCC_ABBA_1	0.3056
p.R1040W	TCGA-B5-A11E	UCEC	TCGA	FPLYED	LIG_APCC_ABBA_1	0.3056
p.P1031S	TCGA-D3-A8GQ	SKCM	TCGA	FPLYED	LIG_APCC_ABBA_1	0.1667
p.P1049S	TCGA-D6-6516	HNSC	TCGA	FPLYED	LIG_APCC_ABBA_1	0.25
p.P1031L	TCGA-EE-A2M6	SKCM	TCGA	FPLYED	LIG_APCC_ABBA_1	0.1667
p.P1056H	TCGA-EY-A215	UCEC	TCGA	FPLYED	LIG_APCC_ABBA_1	0.5
p.E1039K	DO224618	BRCA	ICGC	FPLYED	LIG_APCC_ABBA_1	0.2778
p.E1039K	DO1016	BRCA	ICGC	FPLYED	LIG_APCC_ABBA_1	0.2778
p.E1032A	DO10842	ESAD	ICGC	FPLYED	LIG_APCC_ABBA_1	0.0833
p.E1048K	DO233272	GACA	ICGC	FPLYED	LIG_APCC_ABBA_1	0.2778
p.D1047Y	DO218942	LUAD	ICGC	FPLYED	LIG_APCC_ABBA_1	0.3056
p.E1055V	DO24100	LUAD	ICGC	FPLYED	LIG_APCC_ABBA_1	0.0833
p.P1053S	DO37410	SKCM	ICGC	FPLYED	LIG_APCC_ABBA_1	0.1389
p.P1042A	DO40918	UCEC	ICGC	FPLYED	LIG_APCC_ABBA_1	0.6392
p.E1032D	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	FPLYED	LIG_APCC_ABBA_1	0.0833
p.E1032D	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.0833
p.Y1056C	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	FPLYED	LIG_APCC_ABBA_1	0.5
p.Y1056C	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.5
p.R1033Q	ACH-001737	Leukemia	CCLE	FPLYED	LIG_APCC_ABBA_1	0.5556
p.R1033Q	ACH-002222	Leukemia	CCLE	FPLYED	LIG_APCC_ABBA_1	0.5556
p.R1033Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.5556
p.N1056K	NCI-H250	lung	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.5
p.G1036R	NCI-H524	lung	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.1944
p.P1045L	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.7582
p.R1040Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.3056
p.G1043R	NCI-H524	lung	COSMIC	FPLYED	LIG_APCC_ABBA_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FPLYED

Degron related mutations and impact score

Drug responses associated with PARD3B mutations

All proteins holding degron of FPLYED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEW8	Partitioning defective 3 homolog B	LIG_APCC_ABBA_1	1041:1046	FPLYED	APC,CDC20,FZR1	0.9912	More...