DegronMD

Uniprot ID: Q8TEW8

Source protein: Partitioning defective 3 homolog B

Source gene: PARD3B

Class: DEG_SCF_TRCP1_1

Location: 1014:1019

E3 ligase: BTRC

DEGRON score: 0.9877

ASA_SCORE: 86.8667

COIL: 0.9637

CONS_SCORE: 0.3192

DSS_SCORE: 0.6646

HELIX: 0.0227

FCONS_SCORE: 0.8813

RIG_SCORE: 0.5858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1012C	TCGA-A5-A0G2	UCEC	TCGA	DSGRPT	DEG_SCF_TRCP1_1	0.2778
p.N1007D	TCGA-AJ-A8CW	UCEC	TCGA	DSGRPT	DEG_SCF_TRCP1_1	0.5833
p.A1013V	DO8224	COAD	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.3056
p.A1013V	DO43065	UCEC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.3056
p.T1019M	DO230347	COCA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.7423
p.T1019M	DO51255	SKCM	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.7423
p.L1010P	DO233232	GACA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.2222
p.R1025C	DO233212	GACA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.1667
p.K1005N	DO228976	LICA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.Q1027L	DO230524	LUSC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.1111
p.N1004K	DO52346	LUSC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.0556
p.N1004K	DO229201	THCA	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.0556
p.R1017H	DO228437	MALY	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.7133
p.P1009T	DO37419	SKCM	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.P1009L	DO37419	SKCM	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.R1017C	DO41331	UCEC	ICGC	DSGRPT	DEG_SCF_TRCP1_1	0.719
p.K1028T	SIDM02074	Esophageal Carcinoma	GDSC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.D1024G	SIDM00251	Gastric Carcinoma	GDSC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.D1024G	TGBC11TKB	stomach	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.G1016S	SIDM01228	Melanoma	GDSC	DSGRPT	DEG_SCF_TRCP1_1	0.6993
p.G1016S	CHL-1	skin	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	0.6993
p.G1008R	ACH-001566	Skin Cancer	CCLE	DSGRPT	DEG_SCF_TRCP1_1	0.1667
p.G1008W	ACH-002061	Leukemia	CCLE	DSGRPT	DEG_SCF_TRCP1_1	0.1667
p.N1024K	NCI-H250	lung	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.G1004R	NCI-H524	lung	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	0.0556
p.A1028T	GP5d	large_intestine	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	0.1944
p.R1027H	NCI-SNU-5	stomach	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	0.1111
p.P1010L	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRPT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEW8	Partitioning defective 3 homolog B	DEG_SCF_TRCP1_1	1014:1019	DSGRPT	BTRC	0.9877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRPT

Degron related mutations and impact score

Drug responses associated with PARD3B mutations

All proteins holding degron of DSGRPT