DegronMD

Uniprot ID: Q8TEW8

Source protein: Partitioning defective 3 homolog B

Source gene: PARD3B

Class: LIG_APCC_ABBAyCdc20_2

Location: 244:250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7252

ASA_SCORE: 79.1286

COIL: 0.8164

CONS_SCORE: 0.4958

DSS_SCORE: 0.2395

HELIX: 0.1476

FCONS_SCORE: 0.8752

RIG_SCORE: 0.7769

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G235V	TCGA-85-8355	LUSC	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G235V	DO45488	LUSC	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.F248V	TCGA-A6-5665	COAD	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7068
p.F248V	DO9756	COAD	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7068
p.E250K	TCGA-AA-A022	COAD	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E250K	TCGA-BF-AAP2	SKCM	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E250K	TCGA-EE-A3AE	SKCM	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E250K	DO10647	COAD	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E250K	DO234383	ESAD	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E250K	DO37802	SKCM	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E250K	DO219466	SKCM	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.7022
p.R244W	TCGA-DU-6392	LGG	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R244W	DO22237	LGG	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R244W	SIDM00572	Gastric Carcinoma	GDSC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R244W	SIDM00927	Small Cell Lung Carcinoma	GDSC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R244W	ACH-000871	Lung Cancer	CCLE	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R244W	ACH-000911	Gastric Cancer	CCLE	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R244W	NUGC-3	stomach	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R244W	NCI-H510A	lung	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.8634
p.N259S	TCGA-YD-A9TA	SKCM	TCGA	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.N259S	DO219503	SKCM	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.C253F	DO229041	LICA	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.25
p.N259D	DO45185	LIRI	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E245K	DO222521	MELA	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.591
p.S240I	DO232761	PBCA	ICGC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G235C	SIDM00238	Ovarian Carcinoma	GDSC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G235C	ACH-000947	Ovarian Cancer	CCLE	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G235C	OVK-18	ovary	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A257V	LS-411N	large_intestine	COSMIC	REGLFHE	LIG_APCC_ABBAyCdc20_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: REGLFHE

Degron related mutations and impact score

Drug responses associated with PARD3B mutations

All proteins holding degron of REGLFHE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEW8	Partitioning defective 3 homolog B	LIG_APCC_ABBAyCdc20_2	244:250	REGLFHE	APC,CDC20,FZR1	0.7252	More...