DegronMD

Uniprot ID: Q8TEW8

Source protein: Partitioning defective 3 homolog B

Source gene: PARD3B

Class: DEG_SPOP_SBC_1

Location: 616:620

E3 ligase: SPOP

DEGRON score: 0.734

ASA_SCORE: 82.6

COIL: 0.8876

CONS_SCORE: 0.3547

DSS_SCORE: 0.3353

HELIX: 0.0896

FCONS_SCORE: 1.0753

RIG_SCORE: 0.7492

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y610F	TCGA-18-3417	LUSC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.1667
p.S613G	TCGA-CG-4442	STAD	TCGA	AVTTS	DEG_SPOP_SBC_1	0.25
p.S613C	TCGA-JY-A93E	ESCA	TCGA	AVTTS	DEG_SPOP_SBC_1	0.25
p.R622Q	DO222769	COCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.S606F	DO219918	DLBC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.0556
p.N623D	SIDM01057	Acute Myeloid Leukemia	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00401	Melanoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM01248	Thyroid Gland Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00919	Ovarian Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00945	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM01078	Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00230	Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM01247	Burkitt's Lymphoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00871	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM00872	Breast Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM01167	Thyroid Gland Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM01564	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.N623D	SIDM01699	Chondrosarcoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.25
p.D624E	SIDM00705	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	0.2222
p.D624E	SIDM00696	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	0.2222
p.D624E	ACH-002369	Non-Cancerous	CCLE	AVTTS	DEG_SPOP_SBC_1	0.2222
p.D624E	ACH-002383	Non-Cancerous	CCLE	AVTTS	DEG_SPOP_SBC_1	0.2222
p.P608S	SIDM00789	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.P608S	ACH-000997	Colon/Colorectal Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	0.1111
p.P608S	HCT-15	large_intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.T619N	SIDM00203	Ewing's Sarcoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.7055
p.T619N	ACH-002111	Bone Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	0.7055
p.T619N	EW-11	bone	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.7055
p.Q625K	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.1944
p.H612Y	RD	soft_tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.2222
p.Q613K	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTTS

Degron related mutations and impact score

Drug responses associated with PARD3B mutations

All proteins holding degron of AVTTS