DegronMD

Uniprot ID: O75376

Source protein: Nuclear receptor corepressor 1

Source gene: NCOR1

Class: DEG_SPOP_SBC_1

Location: 2240:2244

E3 ligase: SPOP

DEGRON score: 0.9879

ASA_SCORE: 92.82

COIL: 0.9474

CONS_SCORE: 0.31

DSS_SCORE: 0.4487

HELIX: 0.0178

FCONS_SCORE: 0.9624

RIG_SCORE: 0.7094

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2243K	TCGA-2H-A9GO	ESCA	TCGA	AVTTS	DEG_SPOP_SBC_1	0.7306
p.T2243M	TCGA-4Z-AA81	BLCA	TCGA	AVTTS	DEG_SPOP_SBC_1	0.7423
p.T2243M	TCGA-A5-A0G2	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.7423
p.I2235M	TCGA-BH-A1FC	BRCA	TCGA	AVTTS	DEG_SPOP_SBC_1	0.1944
p.F2254S	TCGA-D3-A8GP	SKCM	TCGA	AVTTS	DEG_SPOP_SBC_1	0.0556
p.S2249C	TCGA-DK-A1AC	BLCA	TCGA	AVTTS	DEG_SPOP_SBC_1	0.1944
p.Q2230H	TCGA-DU-7294	LGG	TCGA	AVTTS	DEG_SPOP_SBC_1	0.0556
p.T2242S	TCGA-DU-8166	LGG	TCGA	AVTTS	DEG_SPOP_SBC_1	0.6005
p.G2251C	TCGA-QK-A6VB	HNSC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.1389
p.S2234F	DO1255	BRCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.1667
p.S2234F	DO8264	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	0.1667
p.K2231T	DO9002	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	0.0833
p.G2238V	DO8514	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.S2232Y	DO41133	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.T2244M	DO42665	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7423
p.H2252Y	SIDM01043	Other Sarcomas	GDSC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.H2252Y	SIDM00857	Melanoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.H2252Y	SIDM00712	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.H2252Y	SIDM01201	Other Blood Cancers	GDSC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.H2252Y	SIDM00713	Mesothelioma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.1111
p.S2253Y	SIDM00193	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.5278
p.S2253Y	ACH-000991	Colon/Colorectal Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	0.5278
p.S2253Y	SNU-81	large_intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.5278
p.K2232T	CW-2	large_intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons