DegronMD - O15042(U2SURP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R539K	TCGA-21-1083	LUSC	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation altering degron motif	0.7237
p.H785R	TCGA-44-4112	LUAD	TCGA	AVTTS	DEG_SPOP_SBC_1	773:777	Mutation rewiring degron network	0.1111
p.S529C	TCGA-64-1676	LUAD	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation rewiring degron network	0.0833
p.A771V	TCGA-A5-A1OF	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	773:777	Mutation rewiring degron network	0.2778
p.Q772H	TCGA-A5-A1OF	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	773:777	Mutation rewiring degron network	0.3056
p.R845C	TCGA-A5-A2K5	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.719
p.R845C	TCGA-EY-A1G8	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.719
p.R845C	ACH-001566	Skin Cancer	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.719
p.F854Y	TCGA-AP-A0LM	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.1667
p.T550S	TCGA-BS-A0U8	UCEC	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation rewiring degron network	0.2222
p.F830L	TCGA-E6-A1LX	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.0556
p.E766D	TCGA-EC-A1NJ	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	773:777	Mutation rewiring degron network	0.1389
p.R845H	TCGA-F5-6814	READ	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.7133
p.L769F	TCGA-GN-A26C	SKCM	TCGA	AVTTS	DEG_SPOP_SBC_1	773:777	Mutation rewiring degron network	0.2222
p.D555H	TCGA-LL-A73Y	BRCA	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation rewiring degron network	0.0833
p.R534Q	DO9002	COAD	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation rewiring degron network	0.2222
p.R534Q	DO41211	UCEC	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation rewiring degron network	0.2222
p.R528H	DO13252	GBM	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation rewiring degron network	0.0556
p.R528C	DO229052	LICA	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation rewiring degron network	0.0556
p.S542L	DO220891	MELA	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation altering degron motif	0.7667
p.S542L	DO36368	PRAD	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation altering degron motif	0.7667
p.S542L	DO51292	SKCM	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation altering degron motif	0.7667
p.S545L	DO229456	SKCA	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation altering degron motif	0.7667
p.P540S	DO47837	STAD	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	538:546	Mutation altering degron motif	0.6752
p.L858F	SIDM00774	Breast Carcinoma	GDSC	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.0556
p.L858F	ACH-000691	Breast Cancer	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.0556
p.L858F	HCC2157	breast	COSMIC	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.0556
p.S837T	SIDM01776	Plasma Cell Myeloma	GDSC	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.25
p.S837T	ACH-001162	Myeloma	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.25
p.R841Q	ACH-001461	Colon/Colorectal Cancer	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation altering degron motif	0.7329
p.Q784H	ACH-002508	Skin Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	773:777	Mutation rewiring degron network	0.1389
p.L857F	HCC2157	breast	COSMIC	KRAKLREIE	DEG_APCC_DBOX_1	840:848	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

U2SURP

UniProt ID: O15042

Entrez ID: 23350

Protein name: U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for U2SURP in