DegronMD

Uniprot ID: O15042

Source protein: U2 snRNP-associated SURP motif-containing protein

Source gene: U2SURP

Class: DEG_APCC_DBOX_1

Location: 840:848

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8201

ASA_SCORE: 89.5444

COIL: 0.2394

CONS_SCORE: 0.4247

DSS_SCORE: 0.4042

HELIX: 0.7564

FCONS_SCORE: 1.0063

RIG_SCORE: 0.7916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R845C	TCGA-A5-A2K5	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	0.719
p.R845C	TCGA-EY-A1G8	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	0.719
p.R845C	ACH-001566	Skin Cancer	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	0.719
p.F854Y	TCGA-AP-A0LM	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	0.1667
p.F830L	TCGA-E6-A1LX	UCEC	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	0.0556
p.R845H	TCGA-F5-6814	READ	TCGA	KRAKLREIE	DEG_APCC_DBOX_1	0.7133
p.L858F	SIDM00774	Breast Carcinoma	GDSC	KRAKLREIE	DEG_APCC_DBOX_1	0.0556
p.L858F	ACH-000691	Breast Cancer	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	0.0556
p.L858F	HCC2157	breast	COSMIC	KRAKLREIE	DEG_APCC_DBOX_1	0.0556
p.S837T	SIDM01776	Plasma Cell Myeloma	GDSC	KRAKLREIE	DEG_APCC_DBOX_1	0.25
p.S837T	ACH-001162	Myeloma	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	0.25
p.R841Q	ACH-001461	Colon/Colorectal Cancer	CCLE	KRAKLREIE	DEG_APCC_DBOX_1	0.7329
p.L857F	HCC2157	breast	COSMIC	KRAKLREIE	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_APCC_DBOX_1	840:848	KRAKLREIE	APC,CDC20,FZR1	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons