DegronMD

Uniprot ID: O15042

Source protein: U2 snRNP-associated SURP motif-containing protein

Source gene: U2SURP

Class: DEG_SPOP_SBC_1

Location: 773:777

E3 ligase: SPOP

DEGRON score: 0.9929

ASA_SCORE: 67.04

COIL: 0.6966

CONS_SCORE: 0.3916

DSS_SCORE: 0.5926

HELIX: 0.2596

FCONS_SCORE: 1.1875

RIG_SCORE: 0.7488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H785R	TCGA-44-4112	LUAD	TCGA	AVTTS	DEG_SPOP_SBC_1	0.1111
p.A771V	TCGA-A5-A1OF	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.2778
p.Q772H	TCGA-A5-A1OF	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.3056
p.E766D	TCGA-EC-A1NJ	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.1389
p.L769F	TCGA-GN-A26C	SKCM	TCGA	AVTTS	DEG_SPOP_SBC_1	0.2222
p.Q784H	ACH-002508	Skin Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons