DegronMD

Uniprot ID: Q9UKM9

Source protein: RNA-binding protein Raly

Source gene: RALY

Class: DEG_SPOP_SBC_1

Location: 172:176

E3 ligase: SPOP

DEGRON score: 0.9427

ASA_SCORE: 72.78

COIL: 0.739

CONS_SCORE: 0.3825

DSS_SCORE: 0.1878

HELIX: 0.1552

FCONS_SCORE: 0.8493

RIG_SCORE: 0.7998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E186K	TCGA-DK-A1A3	BLCA	TCGA	AVTTS	DEG_SPOP_SBC_1	0.0556
p.E170K	DO558	BLCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7222
p.L171M	DO233764	GACA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.3056
p.L171M	DO229055	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.3056
p.I181V	DO22237	LGG	ICGC	AVTTS	DEG_SPOP_SBC_1	0.3056
p.S183F	DO44881	LIHC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.5833
p.R169H	ACH-000088	Non-Cancerous	CCLE	AVTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons