DegronMD - Q86TC9(MYPN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P388S	TCGA-06-5416	GBM	TCGA	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation altering degron motif	0.5641
p.V581I	TCGA-14-0866	GBM	TCGA	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1389
p.P713S	TCGA-16-0849	GBM	TCGA	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1389
p.L912Q	TCGA-43-2581	LUSC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.1111
p.S741C	TCGA-55-6975	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.7541
p.A734T	TCGA-55-7903	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2222
p.H585N	TCGA-56-7222	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.25
p.T730K	TCGA-60-2723	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1111
p.Q379R	TCGA-85-8580	LUSC	TCGA	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1111
p.L544I	TCGA-95-7947	LUAD	TCGA	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.P700S	TCGA-A2-A0CL	BRCA	TCGA	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2778
p.P700S	SIDM00040	Gastric Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2778
p.P700S	ACH-002202	Gastric Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2778
p.P700S	TMK-1	stomach	COSMIC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2778
p.R919C	TCGA-A5-A2K5	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919C	TCGA-AJ-A5DW	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919C	DO44093	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919C	ACH-002509	Skin Cancer	CCLE	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R922H	TCGA-A6-2686	COAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation altering degron motif	0.7133
p.H599Y	TCGA-AP-A051	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1389
p.R919H	TCGA-AZ-6608	COAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919H	TCGA-B5-A3FC	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919H	DO10550	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919H	DO26590	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R919H	MHH-NB-11	autonomic ganglia	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.R922C	TCGA-B5-A3FA	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation altering degron motif	0.719
p.R922C	TCGA-BA-5151	HNSC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation altering degron motif	0.719
p.E917D	TCGA-B6-A0I9	BRCA	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.25
p.T733I	TCGA-BH-A0HI	BRCA	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1944
p.R597H	TCGA-BR-4292	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1944
p.R597H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1944
p.A734S	TCGA-CK-5916	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2222
p.L582M	TCGA-D1-A103	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1667
p.P743Q	TCGA-EB-A431	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.3056
p.T732I	TCGA-EE-A2M5	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1667
p.A699D	TCGA-EI-6514	READ	TCGA	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.25
p.L747F	TCGA-EK-A2R7	CESC	TCGA	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1944
p.E915K	TCGA-FR-A8YC	SKCM	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.1944
p.A554T	TCGA-G2-A2EO	BLCA	TCGA	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.25
p.M913V	TCGA-HU-A4H4	STAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.1389
p.R597C	TCGA-IB-7651	PAAD	TCGA	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1944
p.R597C	TCGA-WE-AAA0	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1944
p.E383K	TCGA-W3-AA1W	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.2222
p.S539R	TCGA-XF-A9SX	BLCA	TCGA	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1111
p.E936K	TCGA-Z6-A8JE	ESCA	TCGA	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.0833
p.E732Q	DO485	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1667
p.E910K	DO220823	BRCA	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.0556
p.S557C	DO49902	CESC	ICGC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1667
p.P924S	DO10510	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation altering degron motif	0.6752
p.R602C	DO227844	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.0556
p.R602C	DO43154	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.0556
p.R602C	DO41542	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.0556
p.Q390E	DO234372	ESAD	ICGC	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation altering degron motif	0.6744
p.N393S	DO233613	GACA	ICGC	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.2778
p.R547W	DO233792	GACA	ICGC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.8634
p.P595Q	DO10880	GBM	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.25
p.P595Q	DO37431	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.25
p.R547L	DO49055	HNSC	ICGC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.8428
p.P593L	DO14606	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.3056
p.S543C	DO15286	HNSC	ICGC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2222
p.K708N	DO229018	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2778
p.V596L	DO229019	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2222
p.Q709H	DO229022	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.25
p.W703L	DO229022	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7015
p.Q387H	DO24467	LUAD	ICGC	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation altering degron motif	0.7582
p.M580L	DO23666	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.1111
p.R919G	DO230538	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.3056
p.N741K	DO230929	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.6918
p.N741K	DO224572	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.6918
p.E917Q	DO26520	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.25
p.G584R	DO26422	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2222
p.G584R	DO37406	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2222
p.G584R	DO51273	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.2222
p.F704Y	DO222363	MELA	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7528
p.T936S	DO229155	NKTL	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.0833
p.P578A	DO33472	PACA	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.0556
p.P913L	DO218904	SKCA	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.1389
p.P924L	DO37567	SKCM	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation altering degron motif	0.7582
p.G695V	DO37447	SKCM	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1389
p.G695W	DO50279	SKCM	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1389
p.D933E	DO51777	STAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.1667
p.D706Y	DO41020	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7325
p.S733Y	DO43041	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1944
p.K587N	DO41903	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.3056
p.A553T	DO42608	UCEC	ICGC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.K932T	DO41235	UCEC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.1944
p.R602H	DO43891	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.0556
p.R713I	DO41488	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1389
p.N698S	SIDM00234	Other Solid Cancers	GDSC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2222
p.N698S	TC-YIK	cervix	COSMIC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2222
p.V744L	SIDM00814	Other Solid Cancers	GDSC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2778
p.V744L	ACH-001401	Adrenal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2778
p.V744L	SW13	adrenal gland	COSMIC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2778
p.T750A	SIDM00537	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1111
p.T750A	ACH-001345	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1111
p.T750A	GP5d	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1111
p.T746A	SIDM01133	Other Solid Cancers	GDSC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2222
p.R377Q	SIDM00220	Ovarian Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.0556
p.T746P	SIDM00980	Gastric Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2222
p.T746P	ACH-000948	Gastric Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2222
p.T746P	23132-87	stomach	COSMIC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2222
p.S741G	SIDM01608	Endometrial Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.6993
p.S741G	ACH-000990	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.6993
p.P728S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0556
p.P728S	ACH-000891	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.0556
p.L747S	ACH-000901	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1944
p.G595E	ACH-000961	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.25
p.P593S	639-V	urinary tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation rewiring degron network	0.3056
p.T931A	SNU-C5	large intestine	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.2222
p.D739N	451Lu	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.6932
p.I921L	HCT-15	large intestine	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation altering degron motif	0.7174
p.G553V	ECC10	stomach	COSMIC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.G553V	CA46	haematopoietic and lymphoid tissue	COSMIC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.G553V	MY-M12	haematopoietic and lymphoid tissue	COSMIC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.R922K	639-V	urinary tract	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation altering degron motif	0.6126
p.T917I	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.25
p.R748H	SK-MEL-2	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1667
p.T936I	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.0833
p.F396I	TE-5	oesophagus	COSMIC	PPTTS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1944
p.K588E	HCE-4	oesophagus	COSMIC	PRSSS	DEG_SPOP_SBC_1	588:592	Mutation altering degron motif	0.7022
p.K705E	LCLC-97TM1	lung	COSMIC	AVTTS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7022
p.I747T	JHOS-2	ovary	COSMIC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1944
p.A551D	SNU-81	large intestine	COSMIC	ANSTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7793
p.P913H	NCI-H1703	lung	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	920:927	Mutation rewiring degron network	0.1389
p.R748C	NCI-H1623	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYPN

UniProt ID: Q86TC9

Entrez ID: 84665

Protein name: Myopalladin (145 kDa sarcomeric protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYPN in