DegronMD

Uniprot ID: Q86TC9

Source protein: Myopalladin

Source gene: MYPN

Class: DEG_SPOP_SBC_1

Location: 547:551

E3 ligase: SPOP

DEGRON score: 0.9532

ASA_SCORE: 78.08

COIL: 0.5546

CONS_SCORE: 0.4579

DSS_SCORE: 0.6543

HELIX: 0.0294

FCONS_SCORE: 1.1504

RIG_SCORE: 0.612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L544I	TCGA-95-7947	LUAD	TCGA	ANSTT	DEG_SPOP_SBC_1	0.25
p.A554T	TCGA-G2-A2EO	BLCA	TCGA	ANSTT	DEG_SPOP_SBC_1	0.25
p.S539R	TCGA-XF-A9SX	BLCA	TCGA	ANSTT	DEG_SPOP_SBC_1	0.1111
p.S557C	DO49902	CESC	ICGC	ANSTT	DEG_SPOP_SBC_1	0.1667
p.R547W	DO233792	GACA	ICGC	ANSTT	DEG_SPOP_SBC_1	0.8634
p.R547L	DO49055	HNSC	ICGC	ANSTT	DEG_SPOP_SBC_1	0.8428
p.S543C	DO15286	HNSC	ICGC	ANSTT	DEG_SPOP_SBC_1	0.2222
p.A553T	DO42608	UCEC	ICGC	ANSTT	DEG_SPOP_SBC_1	0.2778
p.G553V	ECC10	stomach	COSMIC	ANSTT	DEG_SPOP_SBC_1	0.2778
p.G553V	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	ANSTT	DEG_SPOP_SBC_1	0.2778
p.G553V	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	ANSTT	DEG_SPOP_SBC_1	0.2778
p.A551D	SNU-81	large_intestine	COSMIC	ANSTT	DEG_SPOP_SBC_1	0.7793

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	433:437	ANSTT	SPOP	0.6609	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	540:544	ANSTT	SPOP	0.9782	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	547:551	ANSTT	SPOP	0.9532	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	1569:1573	ANSTT	SPOP	0.992	More...
Q7Z2G1	Histone H2B type W-T	DEG_SPOP_SBC_1	50:54	ANSTT	SPOP	0.8915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons