DegronMD

Uniprot ID: O94876

Source protein: Transmembrane and coiled-coil domains protein 1

Source gene: TMCC1

Class: DEG_SPOP_SBC_1

Location: 433:437

E3 ligase: SPOP

DEGRON score: 0.6609

ASA_SCORE: 81.98

COIL: 0.7652

CONS_SCORE: 0.4347

DSS_SCORE: 0.4123

HELIX: 0.1348

FCONS_SCORE: 0.8845

RIG_SCORE: 0.6385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S424C	TCGA-4Z-AA7W	BLCA	TCGA	ANSTT	DEG_SPOP_SBC_1	0.0833
p.A441T	TCGA-BR-8081	STAD	TCGA	ANSTT	DEG_SPOP_SBC_1	0.2222
p.A441T	TCGA-VS-A8EH	CESC	TCGA	ANSTT	DEG_SPOP_SBC_1	0.2222
p.S428L	TCGA-D7-A74B	STAD	TCGA	ANSTT	DEG_SPOP_SBC_1	0.1944
p.T437I	SIDM00251	Gastric Carcinoma	GDSC	ANSTT	DEG_SPOP_SBC_1	0.7078
p.T437I	TGBC11TKB	stomach	COSMIC	ANSTT	DEG_SPOP_SBC_1	0.7078
p.Q426E	TK10	kidney	COSMIC	ANSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	433:437	ANSTT	SPOP	0.6609	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	540:544	ANSTT	SPOP	0.9782	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	547:551	ANSTT	SPOP	0.9532	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	1569:1573	ANSTT	SPOP	0.992	More...
Q7Z2G1	Histone H2B type W-T	DEG_SPOP_SBC_1	50:54	ANSTT	SPOP	0.8915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons