DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: DEG_SPOP_SBC_1

Location: 1569:1573

E3 ligase: SPOP

DEGRON score: 0.992

ASA_SCORE: 91.04

COIL: 0.9286

CONS_SCORE: 0.4618

DSS_SCORE: 0.5927

HELIX: 0.039

FCONS_SCORE: 1.2007

RIG_SCORE: 0.6337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1571N	TCGA-06-5416	GBM	TCGA	ANSTT	DEG_SPOP_SBC_1	0.7069
p.S1571N	DO10880	GBM	ICGC	ANSTT	DEG_SPOP_SBC_1	0.7069
p.D1574N	TCGA-86-8056	LUAD	TCGA	ANSTT	DEG_SPOP_SBC_1	0.3056
p.D1574N	DO24950	LUAD	ICGC	ANSTT	DEG_SPOP_SBC_1	0.3056
p.L1582P	TCGA-B5-A3FA	UCEC	TCGA	ANSTT	DEG_SPOP_SBC_1	0.0833
p.L1582P	DO52402	UCEC	ICGC	ANSTT	DEG_SPOP_SBC_1	0.0833
p.E1578Q	TCGA-JW-A5VL	CESC	TCGA	ANSTT	DEG_SPOP_SBC_1	0.1944
p.E1578Q	DO49976	CESC	ICGC	ANSTT	DEG_SPOP_SBC_1	0.1944
p.E1567Q	ACH-000975	Lung Cancer	CCLE	ANSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	433:437	ANSTT	SPOP	0.6609	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	540:544	ANSTT	SPOP	0.9782	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	547:551	ANSTT	SPOP	0.9532	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	1569:1573	ANSTT	SPOP	0.992	More...
Q7Z2G1	Histone H2B type W-T	DEG_SPOP_SBC_1	50:54	ANSTT	SPOP	0.8915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons