DegronMD - O94876(TMCC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S424C	TCGA-4Z-AA7W	BLCA	TCGA	ANSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.0833
p.A172P	TCGA-BH-A0E6	BRCA	TCGA	APTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.A441T	TCGA-BR-8081	STAD	TCGA	ANSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.2222
p.A441T	TCGA-VS-A8EH	CESC	TCGA	ANSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.2222
p.S428L	TCGA-D7-A74B	STAD	TCGA	ANSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1944
p.Q203K	TCGA-EE-A2MG	SKCM	TCGA	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944
p.Q203K	DO37421	SKCM	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944
p.Y167C	DO10140	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0833
p.Y167C	DO10140	COAD	ICGC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.T148P	DO50450	ESAD	ICGC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1667
p.A214V	DO233865	GACA	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2778
p.A214V	DO38867	STAD	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2778
p.R146W	DO233935	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1111
p.R146W	DO15975	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1111
p.S215N	DO228957	LICA	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.25
p.M209V	DO52193	LIHC	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7208
p.T148A	DO48746	LIRI	ICGC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1667
p.E157D	DO24411	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.6758
p.Q216E	DO26981	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2222
p.Q216E	ACH-001208	Kidney Cancer	CCLE	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2222
p.Q216E	TK10	kidney	COSMIC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2222
p.S208I	DO26449	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7341
p.R220Q	DO222532	MELA	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1111
p.S200N	DO232761	PBCA	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1111
p.S168P	DO229259	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.S168P	DO229259	THCA	ICGC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.A207T	DO41235	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.3056
p.S165R	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7427
p.S165R	ACH-000660	Lymphoma	CCLE	APTSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7427
p.S165R	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7427
p.T159I	SIDM01176	B-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation blocking phosphorylation signal	0.75
p.T159I	SIDM01176	B-Lymphoblastic Leukemia	GDSC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.6944
p.T159I	ACH-000059	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation blocking phosphorylation signal	0.75
p.T159I	ACH-000059	Leukemia	CCLE	APTSS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.6944
p.T159I	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation blocking phosphorylation signal	0.75
p.T159I	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.6944
p.T437I	SIDM00251	Gastric Carcinoma	GDSC	ANSTT	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.7078
p.T437I	TGBC11TKB	stomach	COSMIC	ANSTT	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.7078
p.Q172H	ACH-000868	Lung Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.E176K	ACH-000987	Skin Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0556
p.E176K	Mewo	skin	COSMIC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0556
p.Q426E	TK10	kidney	COSMIC	ANSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1389
p.E168Q	UM-UC-3	urinary tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.0556
p.E168Q	UM-UC-3	urinary tract	COSMIC	APTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.R146Q	G-MEL	skin	COSMIC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.1111
p.K150R	NCI-H1299	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2222

Kaplan plot for TMCC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMCC1

UniProt ID: O94876

Entrez ID: 23023

Protein name: Transmembrane and coiled-coil domains protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMCC1 in