DegronMD

Uniprot ID: O94876

Source protein: Transmembrane and coiled-coil domains protein 1

Source gene: TMCC1

Class: DEG_SPOP_SBC_1

Location: 208:212

E3 ligase: SPOP

DEGRON score: 0.6543

ASA_SCORE: 61.96

COIL: 0.7512

CONS_SCORE: 0.3764

DSS_SCORE: 0.5416

HELIX: 0.1588

FCONS_SCORE: 1.0196

RIG_SCORE: 0.6087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q203K	TCGA-EE-A2MG	SKCM	TCGA	VASST	DEG_SPOP_SBC_1	0.1944
p.Q203K	DO37421	SKCM	ICGC	VASST	DEG_SPOP_SBC_1	0.1944
p.A214V	DO233865	GACA	ICGC	VASST	DEG_SPOP_SBC_1	0.2778
p.A214V	DO38867	STAD	ICGC	VASST	DEG_SPOP_SBC_1	0.2778
p.S215N	DO228957	LICA	ICGC	VASST	DEG_SPOP_SBC_1	0.25
p.M209V	DO52193	LIHC	ICGC	VASST	DEG_SPOP_SBC_1	0.7208
p.Q216E	DO26981	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.2222
p.Q216E	ACH-001208	Kidney Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.2222
p.Q216E	TK10	kidney	COSMIC	VASST	DEG_SPOP_SBC_1	0.2222
p.S208I	DO26449	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.7341
p.R220Q	DO222532	MELA	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.S200N	DO232761	PBCA	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.A207T	DO41235	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons