DegronMD

Uniprot ID: Q7RTP6

Source protein: [F-actin]-monooxygenase MICAL3

Source gene: MICAL3

Class: DEG_SPOP_SBC_1

Location: 860:864

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 77.18

COIL: 0.8346

CONS_SCORE: 0.5021

DSS_SCORE: 0.67

HELIX: 0.1082

FCONS_SCORE: 1.0624

RIG_SCORE: 0.6573

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T867S	TCGA-28-2506	GBM	TCGA	VASST	DEG_SPOP_SBC_1	0.6944
p.T867S	TCGA-Y8-A898	KIRP	TCGA	VASST	DEG_SPOP_SBC_1	0.6944
p.T867S	DO11585	GBM	ICGC	VASST	DEG_SPOP_SBC_1	0.6944
p.T867S	DO49804	KIRP	ICGC	VASST	DEG_SPOP_SBC_1	0.6944
p.A857V	TCGA-CG-4442	STAD	TCGA	VASST	DEG_SPOP_SBC_1	0.25
p.A857V	DO232761	PBCA	ICGC	VASST	DEG_SPOP_SBC_1	0.25
p.A857V	DO38380	STAD	ICGC	VASST	DEG_SPOP_SBC_1	0.25
p.E865K	TCGA-CQ-5333	HNSC	TCGA	VASST	DEG_SPOP_SBC_1	0.3056
p.E865K	DO14218	HNSC	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.R856Q	TCGA-D7-8576	STAD	TCGA	VASST	DEG_SPOP_SBC_1	0.2222
p.R856Q	DO47977	STAD	ICGC	VASST	DEG_SPOP_SBC_1	0.2222
p.V860M	TCGA-DD-AACZ	LIHC	TCGA	VASST	DEG_SPOP_SBC_1	0.7208
p.V860M	DO52216	LIHC	ICGC	VASST	DEG_SPOP_SBC_1	0.7208
p.V860M	SIDM00188	Kidney Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.7208
p.V860M	SIDM00313	Hodgkin's Lymphoma	GDSC	VASST	DEG_SPOP_SBC_1	0.7208
p.V860M	SIDM01711	Non-Cancerous	GDSC	VASST	DEG_SPOP_SBC_1	0.7208
p.V860M	SIDM01059	Melanoma	GDSC	VASST	DEG_SPOP_SBC_1	0.7208
p.D852G	TCGA-Q1-A5R3	CESC	TCGA	VASST	DEG_SPOP_SBC_1	0.1111
p.D852G	DO49008	CESC	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.D852G	SIDM00889	Cervical Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.1111
p.D852G	ACH-001333	Cervical Cancer	CCLE	VASST	DEG_SPOP_SBC_1	0.1111
p.D852G	C-33-A	cervix	COSMIC	VASST	DEG_SPOP_SBC_1	0.1111
p.Q855E	DO45448	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.1944
p.A859V	DO220886	MELA	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.G874C	DO27933	ORCA	ICGC	VASST	DEG_SPOP_SBC_1	0.0556
p.N854D	DO38815	STAD	ICGC	VASST	DEG_SPOP_SBC_1	0.1667
p.L865I	DO41999	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.E850D	SIDM01151	Hepatocellular Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.0556
p.E850D	SNU-182	liver	COSMIC	VASST	DEG_SPOP_SBC_1	0.0556
p.A864T	SIDM00845	Burkitt's Lymphoma	GDSC	VASST	DEG_SPOP_SBC_1	0.7139
p.A864T	SIDM00461	Acute Myeloid Leukemia	GDSC	VASST	DEG_SPOP_SBC_1	0.7139
p.A864T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASST	DEG_SPOP_SBC_1	0.7139
p.L865R	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.3056
p.L865R	NCI-H1703	lung	COSMIC	VASST	DEG_SPOP_SBC_1	0.3056
p.G866R	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	VASST	DEG_SPOP_SBC_1	0.2778
p.M874I	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VASST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASST

Degron related mutations and impact score

Drug responses associated with MICAL3 mutations

All proteins holding degron of VASST