DegronMD - Q9UI36(DACH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q594K	TCGA-09-2044	OV	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation rewiring degron network	0.3056
p.K601N	TCGA-22-5480	LUSC	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation rewiring degron network	0.1111
p.V593I	TCGA-CG-5721	STAD	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation altering degron motif	0.7076
p.D603N	TCGA-ER-A19O	SKCM	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation rewiring degron network	0.0556
p.D603G	TCGA-FI-A2D5	UCEC	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation rewiring degron network	0.0556
p.E596K	TCGA-FS-A1ZA	SKCM	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation rewiring degron network	0.25
p.D584H	TCGA-GC-A4ZW	BLCA	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation blocking phosphorylation signal	0.75
p.G577R	TCGA-MQ-A4LM	MESO	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation rewiring degron network	0.1111
p.G123C	DO218075	ORCA	ICGC	VASST	DEG_SPOP_SBC_1	128:132	Mutation rewiring degron network	0.1944
p.S125G	ACH-001034	Bone Cancer	CCLE	VASST	DEG_SPOP_SBC_1	128:132	Mutation rewiring degron network	0.25
p.A732D	SAS	upper aerodigestive tract	COSMIC	LTPEIE	DEG_SCF_FBW7_2	726:731	Mutation rewiring degron network	0.3056
p.P583A	WM278	skin	COSMIC	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation rewiring degron network	0.2778
p.S735N	HCT-15	large intestine	COSMIC	LTPEIE	DEG_SCF_FBW7_2	726:731	Mutation blocking phosphorylation signal	0.6667
p.T582I	HCC1954	breast	COSMIC	ARDSLDKLS	DEG_APCC_DBOX_1	585:593	Mutation blocking phosphorylation signal	0.6944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons