DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VASST
Uniprot ID:
Q9UI36
Source protein:
Dachshund homolog 1
Source gene:
DACH1
Class:
DEG_SPOP_SBC_1
Location:
128:132
E3 ligase:
SPOP
DEGRON score:
0.9985
ASA_SCORE:
80.42
COIL:
0.931
CONS_SCORE:
0.3523
DSS_SCORE:
0.4777
HELIX:
0.0272
FCONS_SCORE:
0.9811
RIG_SCORE:
0.6401
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G123C
DO218075
ORCA
ICGC
VASST
DEG_SPOP_SBC_1
0.1944
p.S125G
ACH-001034
Bone Cancer
CCLE
VASST
DEG_SPOP_SBC_1
0.25
Drug responses associated with DACH1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VASST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94876
Transmembrane and coiled-coil domains protein 1
DEG_SPOP_SBC_1
208:212
VASST
SPOP
0.6543
More...
P10071
Transcriptional activator GLI3
DEG_SPOP_SBC_1
34:38
VASST
SPOP
0.9984
More...
P22670
MHC class II regulatory factor RFX1
DEG_SPOP_SBC_1
366:370
VASST
SPOP
0.601
More...
P35789
Zinc finger protein 93
DEG_SPOP_SBC_1
435:439
VASST
SPOP
0.6657
More...
P52594
Arf-GAP domain and FG repeat-containing protein 1
DEG_SPOP_SBC_1
444:448
VASST
SPOP
0.937
More...
Q14008
Cytoskeleton-associated protein 5
DEG_SPOP_SBC_1
1971:1975
VASST
SPOP
0.9917
More...
Q7RTP6
[F-actin]-monooxygenase MICAL3
DEG_SPOP_SBC_1
860:864
VASST
SPOP
0.9989
More...
Q96F05
Uncharacterized protein C11orf24
DEG_SPOP_SBC_1
110:114
VASST
SPOP
0.9912
More...
Q9H2X6
Homeodomain-interacting protein kinase 2
DEG_SPOP_SBC_1
862:866
VASST
SPOP
0.9864
More...
Q9H4H8
Protein FAM83D
DEG_SPOP_SBC_1
487:491
VASST
SPOP
0.9868
More...
Q9UHD8
Septin-9
DEG_SPOP_SBC_1
56:60
VASST
SPOP
0.9944
More...
Q9UI36
Dachshund homolog 1
DEG_SPOP_SBC_1
128:132
VASST
SPOP
0.9985
More...
Q9Y3S1
Serine/threonine-protein kinase WNK2
DEG_SPOP_SBC_1
2007:2011
VASST
SPOP
0.9246
More...
Q9Y4G8
Rap guanine nucleotide exchange factor 2
DEG_SPOP_SBC_1
1380:1384
VASST
SPOP
0.9098
More...
Q8NCQ7
Protein PROCA1
DEG_SPOP_SBC_1
46:50
VASST
SPOP
0.8048
More...