DegronMD - Q9H4H8(FAM83D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P483H	TCGA-17-Z025	LUAD	TCGA	VASST	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2222
p.K506N	TCGA-24-1103	OV	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1944
p.K506N	DO28089	OV	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1944
p.S512C	TCGA-34-5231	LUSC	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.7541
p.S512C	TCGA-BA-A6DL	HNSC	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.7541
p.S512C	DO52035	HNSC	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.7541
p.S512C	DO26772	LUSC	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.7541
p.S503A	TCGA-39-5037	LUSC	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1111
p.S503A	DO27429	LUSC	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1111
p.T489A	TCGA-66-2783	LUSC	TCGA	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.7139
p.T489A	DO26452	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.7139
p.V499I	TCGA-AA-A010	COAD	TCGA	VASST	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.1111
p.S488P	TCGA-AX-A3FV	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.6752
p.S488P	DO219767	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.6752
p.R347Q	TCGA-B5-A11E	UCEC	TCGA	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.0833
p.R347Q	TCGA-D9-A6EC	SKCM	TCGA	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.0833
p.R347Q	DO50291	SKCM	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.0833
p.R347Q	DO41644	UCEC	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.0833
p.R347Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.0833
p.R347Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.0833
p.R347Q	SNU-81	large intestine	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.0833
p.K340T	TCGA-D9-A6EC	SKCM	TCGA	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation blocking phosphorylation signal	0.7222
p.K340T	DO50291	SKCM	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation blocking phosphorylation signal	0.7222
p.V517A	TCGA-EE-A29G	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.6936
p.V517A	DO47303	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.6936
p.V517A	ACH-001127	Leukemia	CCLE	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.6936
p.V517A	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.6936
p.S513F	TCGA-EE-A29L	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.7982
p.S513F	DO222599	MELA	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.7982
p.S513F	DO37835	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.7982
p.P524H	TCGA-EE-A2MT	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1389
p.P524H	DO38051	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1389
p.E40D	TCGA-ER-A19P	SKCM	TCGA	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6758
p.E40D	DO47623	SKCM	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6758
p.G491W	TCGA-ER-A2NH	SKCM	TCGA	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.7825
p.G491W	DO47683	SKCM	ICGC	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.7825
p.G485E	TCGA-IB-7651	PAAD	TCGA	VASST	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2778
p.G485E	DO46657	PAAD	ICGC	VASST	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2778
p.P524L	TCGA-QB-A6FS	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1389
p.P524L	DO48654	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.1389
p.G37S	TCGA-W3-AA1R	SKCM	TCGA	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6993
p.G37S	DO51275	SKCM	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6993
p.V41L	DO221311	AML	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.3056
p.V41L	DO229013	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.3056
p.V41L	DO229016	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.3056
p.V41L	DO229003	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.3056
p.V41L	DO229005	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.3056
p.V41L	DO234285	ESAD	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.3056
p.V41L	DO230527	LUSC	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.3056
p.E36Q	DO225204	BRCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6744
p.E36Q	ACH-001570	Skin Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6744
p.A32T	DO222953	BTCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.7139
p.F335V	DO230309	COCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7068
p.N339D	DO227976	COCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation blocking phosphorylation signal	0.75
p.L34V	DO222309	DLBC	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.5654
p.S337I	DO222758	ESCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7341
p.L344I	DO233624	GACA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.1667
p.S26I	DO228911	LICA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.1667
p.A518S	DO229018	LICA	ICGC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation rewiring degron network	0.3056
p.V494F	DO231690	LINC	ICGC	VASST	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.25
p.P48L	DO224563	LUSC	ICGC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.1111
p.R484Q	DO222396	MELA	ICGC	VASST	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.25
p.S333C	DO222843	MELA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7541
p.P326S	DO52132	PAEN	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.2222
p.M332V	SIDM02059	Colorectal Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.6097
p.G327D	SIDM01265	Plasma Cell Myeloma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM00933	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM00773	Non-Cancerous	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM01117	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM00875	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM00863	Burkitt's Lymphoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM00721	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM00774	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM01752	Pancreatic Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327D	SIDM01387	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.R333W	SIDM00472	Ovarian Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7523
p.R333W	PEO1	ovary	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7523
p.H515Y	SIDM01017	B-Lymphoblastic Leukemia	GDSC	LGTPHLE	DEG_SCF_FBW7_2	511:517	Mutation altering degron motif	0.6118
p.G327C	SIDM00650	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.G327C	NCI-H128	lung	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.25
p.E37K	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.591
p.E37K	DB	haematopoietic and lymphoid tissue	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.591
p.A35S	SIDM00272	Breast Carcinoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6477
p.A35S	MDA-MB-453	breast	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation altering degron motif	0.6477
p.L326M	SIDM00373	Endometrial Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.2222
p.L326M	SNG-M	endometrium	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation rewiring degron network	0.2222
p.V487A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.5825
p.V487A	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VASST	DEG_SPOP_SBC_1	487:491	Mutation altering degron motif	0.5825
p.R331Q	SIDM00150	Colorectal Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7329
p.R331Q	KM12	large intestine	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.7329
p.F28L	SIDM01612	Endometrial Carcinoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.2222
p.P24S	SIDM01387	Small Cell Lung Carcinoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.1111
p.R22P	ACH-000213	Pancreatic Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.R22P	ACH-000265	Pancreatic Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.R22P	ACH-000347	Pancreatic Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.R22P	ACH-000443	Ovarian Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.R22P	ACH-000560	Gastric Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.R22P	ACH-000693	Esophageal Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.R22P	ACH-000745	Myeloma	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.R22P	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.0556
p.Q336K	ACH-000939	Sarcoma	CCLE	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.6944
p.Q336K	SK-UT-1	soft tissue	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	330:338	Mutation altering degron motif	0.6944
p.P42S	ACH-002051	Lung Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.2778
p.P42S	LU-134-A	lung	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.2778
p.P42H	ACH-002128	Lung Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.2778
p.P42H	H2722	pleura	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	32:40	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM83D

UniProt ID: Q9H4H8

Entrez ID: 81610

Protein name: Protein FAM83D (Spindle protein CHICA)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM83D in