DegronMD

Uniprot ID: Q9H4H8

Source protein: Protein FAM83D

Source gene: FAM83D

Class: DEG_SCF_FBW7_2

Location: 511:517

E3 ligase: FBXW7

DEGRON score: 0.9399

ASA_SCORE: 81.0857

COIL: 0.8247

CONS_SCORE: 0.5011

DSS_SCORE: 0.2607

HELIX: 0.1117

FCONS_SCORE: 0.7851

RIG_SCORE: 0.7897

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K506N	TCGA-24-1103	OV	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.1944
p.K506N	DO28089	OV	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.1944
p.S512C	TCGA-34-5231	LUSC	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.7541
p.S512C	TCGA-BA-A6DL	HNSC	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.7541
p.S512C	DO52035	HNSC	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.7541
p.S512C	DO26772	LUSC	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.7541
p.S503A	TCGA-39-5037	LUSC	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.1111
p.S503A	DO27429	LUSC	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.1111
p.V517A	TCGA-EE-A29G	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.6936
p.V517A	DO47303	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.6936
p.V517A	ACH-001127	Leukemia	CCLE	LGTPHLE	DEG_SCF_FBW7_2	0.6936
p.V517A	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LGTPHLE	DEG_SCF_FBW7_2	0.6936
p.S513F	TCGA-EE-A29L	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.7982
p.S513F	DO222599	MELA	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.7982
p.S513F	DO37835	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.7982
p.P524H	TCGA-EE-A2MT	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.1389
p.P524H	DO38051	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.1389
p.P524L	TCGA-QB-A6FS	SKCM	TCGA	LGTPHLE	DEG_SCF_FBW7_2	0.1389
p.P524L	DO48654	SKCM	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.1389
p.A518S	DO229018	LICA	ICGC	LGTPHLE	DEG_SCF_FBW7_2	0.3056
p.H515Y	SIDM01017	B-Lymphoblastic Leukemia	GDSC	LGTPHLE	DEG_SCF_FBW7_2	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4H8	Protein FAM83D	DEG_SCF_FBW7_2	511:517	LGTPHLE	FBXW7	0.9399	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons