DegronMD

Uniprot ID: Q9H4H8

Source protein: Protein FAM83D

Source gene: FAM83D

Class: DEG_APCC_DBOX_1

Location: 330:338

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9841

ASA_SCORE: 93.8667

COIL: 0.3859

CONS_SCORE: 0.76

DSS_SCORE: 0.485

HELIX: 0.5874

FCONS_SCORE: 1.1159

RIG_SCORE: 0.7614

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R347Q	TCGA-B5-A11E	UCEC	TCGA	LRMRLARLS	DEG_APCC_DBOX_1	0.0833
p.R347Q	TCGA-D9-A6EC	SKCM	TCGA	LRMRLARLS	DEG_APCC_DBOX_1	0.0833
p.R347Q	DO50291	SKCM	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.0833
p.R347Q	DO41644	UCEC	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.0833
p.R347Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LRMRLARLS	DEG_APCC_DBOX_1	0.0833
p.R347Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRMRLARLS	DEG_APCC_DBOX_1	0.0833
p.R347Q	SNU-81	large_intestine	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.0833
p.K340T	TCGA-D9-A6EC	SKCM	TCGA	LRMRLARLS	DEG_APCC_DBOX_1	0.7222
p.K340T	DO50291	SKCM	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7222
p.F335V	DO230309	COCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7068
p.N339D	DO227976	COCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.75
p.S337I	DO222758	ESCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7341
p.L344I	DO233624	GACA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.1667
p.S333C	DO222843	MELA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7541
p.P326S	DO52132	PAEN	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.2222
p.M332V	SIDM02059	Colorectal Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.6097
p.G327D	SIDM01265	Plasma Cell Myeloma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00933	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00773	Non-Cancerous	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01117	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00875	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00863	Burkitt's Lymphoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00721	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00774	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01752	Pancreatic Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01387	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.R333W	SIDM00472	Ovarian Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.7523
p.R333W	PEO1	ovary	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.7523
p.G327C	SIDM00650	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327C	NCI-H128	lung	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.L326M	SIDM00373	Endometrial Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.2222
p.L326M	SNG-M	endometrium	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.2222
p.R331Q	SIDM00150	Colorectal Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.7329
p.R331Q	KM12	large_intestine	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.7329
p.Q336K	ACH-000939	Sarcoma	CCLE	LRMRLARLS	DEG_APCC_DBOX_1	0.6944
p.Q336K	SK-UT-1	soft_tissue	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRMRLARLS

Degron related mutations and impact score

Drug responses associated with FAM83D mutations

All proteins holding degron of LRMRLARLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4H8	Protein FAM83D	DEG_APCC_DBOX_1	330:338	LRMRLARLS	APC,CDC20,FZR1	0.9841	More...