DegronMD

Uniprot ID: Q9H4H8

Source protein: Protein FAM83D

Source gene: FAM83D

Class: DEG_APCC_DBOX_1

Location: 330:338

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9841

ASA_SCORE: 93.8667

COIL: 0.3859

CONS_SCORE: 0.76

DSS_SCORE: 0.485

HELIX: 0.5874

FCONS_SCORE: 1.1159

RIG_SCORE: 0.7614

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S333C	DO222843	MELA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7541
p.R333W	SIDM00472	Ovarian Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.7523
p.R333W	PEO1	ovary	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.7523
p.N339D	DO227976	COCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.75
p.S337I	DO222758	ESCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7341
p.R331Q	SIDM00150	Colorectal Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.7329
p.R331Q	KM12	large_intestine	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.7329
p.K340T	TCGA-D9-A6EC	SKCM	TCGA	LRMRLARLS	DEG_APCC_DBOX_1	0.7222
p.K340T	DO50291	SKCM	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7222
p.F335V	DO230309	COCA	ICGC	LRMRLARLS	DEG_APCC_DBOX_1	0.7068
p.Q336K	ACH-000939	Sarcoma	CCLE	LRMRLARLS	DEG_APCC_DBOX_1	0.6944
p.Q336K	SK-UT-1	soft_tissue	COSMIC	LRMRLARLS	DEG_APCC_DBOX_1	0.6944
p.M332V	SIDM02059	Colorectal Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.6097
p.G327D	SIDM01265	Plasma Cell Myeloma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00933	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00773	Non-Cancerous	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01117	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00875	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00863	Burkitt's Lymphoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00721	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM00774	Breast Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01752	Pancreatic Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25
p.G327D	SIDM01387	Small Cell Lung Carcinoma	GDSC	LRMRLARLS	DEG_APCC_DBOX_1	0.25

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Drug responses associated with FAM83D mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRMRLARLS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4H8	Protein FAM83D	DEG_APCC_DBOX_1	330:338	LRMRLARLS	APC,CDC20,FZR1	0.9841	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRMRLARLS

Degron related mutations and impact score

Drug responses associated with FAM83D mutations

All proteins holding degron of LRMRLARLS