DegronMD

Uniprot ID: Q9H4H8

Source protein: Protein FAM83D

Source gene: FAM83D

Class: DEG_APCC_DBOX_1

Location: 32:40

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8345

ASA_SCORE: 27.9667

COIL: 0.0106

CONS_SCORE: 0.9049

DSS_SCORE: 0.2837

HELIX: 0.9887

FCONS_SCORE: 1.1733

RIG_SCORE: 0.7989

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E40D	TCGA-ER-A19P	SKCM	TCGA	RRLALEELV	DEG_APCC_DBOX_1	0.6758
p.E40D	DO47623	SKCM	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.6758
p.G37S	TCGA-W3-AA1R	SKCM	TCGA	RRLALEELV	DEG_APCC_DBOX_1	0.6993
p.G37S	DO51275	SKCM	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.6993
p.V41L	DO221311	AML	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.3056
p.V41L	DO229013	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.3056
p.V41L	DO229016	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.3056
p.V41L	DO229003	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.3056
p.V41L	DO229005	COCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.3056
p.V41L	DO234285	ESAD	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.3056
p.V41L	DO230527	LUSC	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.3056
p.E36Q	DO225204	BRCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.6744
p.E36Q	ACH-001570	Skin Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.6744
p.A32T	DO222953	BTCA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.7139
p.L34V	DO222309	DLBC	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.5654
p.S26I	DO228911	LICA	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.1667
p.P48L	DO224563	LUSC	ICGC	RRLALEELV	DEG_APCC_DBOX_1	0.1111
p.E37K	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	0.591
p.E37K	DB	haematopoietic_and_lymphoid_tissue	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	0.591
p.A35S	SIDM00272	Breast Carcinoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	0.6477
p.A35S	MDA-MB-453	breast	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	0.6477
p.F28L	SIDM01612	Endometrial Carcinoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	0.2222
p.P24S	SIDM01387	Small Cell Lung Carcinoma	GDSC	RRLALEELV	DEG_APCC_DBOX_1	0.1111
p.R22P	ACH-000213	Pancreatic Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.R22P	ACH-000265	Pancreatic Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.R22P	ACH-000347	Pancreatic Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.R22P	ACH-000443	Ovarian Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.R22P	ACH-000560	Gastric Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.R22P	ACH-000693	Esophageal Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.R22P	ACH-000745	Myeloma	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.R22P	ACH-000978	Endometrial/Uterine Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.0556
p.P42S	ACH-002051	Lung Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.2778
p.P42S	LU-134-A	lung	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	0.2778
p.P42H	ACH-002128	Lung Cancer	CCLE	RRLALEELV	DEG_APCC_DBOX_1	0.2778
p.P42H	H2722	pleura	COSMIC	RRLALEELV	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRLALEELV

Degron related mutations and impact score

Drug responses associated with FAM83D mutations

All proteins holding degron of RRLALEELV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4H8	Protein FAM83D	DEG_APCC_DBOX_1	32:40	RRLALEELV	APC,CDC20,FZR1	0.8345	More...