DegronMD - Q8NCQ7(PROCA1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A55T	TCGA-06-5416	GBM	TCGA	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.A55T	TCGA-DU-6392	LGG	TCGA	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.A55T	TCGA-N7-A4Y0	UCS	TCGA	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.A55T	SIDM00789	Colorectal Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.A55T	HCT-15	large intestine	COSMIC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.Q318K	TCGA-77-8148	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.S327F	TCGA-AA-3697	COAD	TCGA	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7982
p.P328T	TCGA-BT-A20J	BLCA	TCGA	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.R320G	TCGA-G2-A3IE	BLCA	TCGA	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.R325K	TCGA-V5-A7RE	ESCA	TCGA	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7237
p.D37H	TCGA-V5-A7RE	ESCA	TCGA	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833
p.V322I	TCGA-Z2-A8RT	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.P330T	DO457	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation substituting flanking lysine	0.3611
p.R322G	DO767	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.S329F	DO8424	COAD	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2778
p.C42Y	DO233276	GACA	ICGC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.2222
p.A57T	DO10880	GBM	ICGC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1389
p.A57T	DO22237	LGG	ICGC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1389
p.N325K	DO229015	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6918
p.H45Q	DO229041	LICA	ICGC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.R327T	DO230961	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7876
p.R327T	DO224594	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7876
p.Q320K	DO26458	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.V324I	DO51301	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7076
p.Q45H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.Q45H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VASST	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.3056
p.A314V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.A314V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.S327L	RC-K8	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7667
p.S327L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7667
p.S327L	NCCIT	testis	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7667
p.S327L	5637	urinary tract	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7667
p.S327L	JHH-7	liver	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7667
p.S327L	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7667
p.S327L	DSH1	urinary tract	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7667
p.D321E	HSC-2	upper aerodigestive tract	COSMIC	VESSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PROCA1

UniProt ID: Q8NCQ7

Entrez ID: 147011

Protein name: Protein PROCA1 (Protein interacting with cyclin A1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PROCA1 in