DegronMD

Uniprot ID: Q8NCQ7

Source protein: Protein PROCA1

Source gene: PROCA1

Class: DEG_SPOP_SBC_1

Location: 323:327

E3 ligase: SPOP

DEGRON score: 0.5806

ASA_SCORE: 89.36

COIL: 0.9388

CONS_SCORE: 0.646

DSS_SCORE: 0.711

HELIX: 0.0342

FCONS_SCORE: 0.9525

RIG_SCORE: 0.6305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q318K	TCGA-77-8148	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	0.1944
p.S327F	TCGA-AA-3697	COAD	TCGA	VESSS	DEG_SPOP_SBC_1	0.7982
p.P328T	TCGA-BT-A20J	BLCA	TCGA	VESSS	DEG_SPOP_SBC_1	0.3056
p.R320G	TCGA-G2-A3IE	BLCA	TCGA	VESSS	DEG_SPOP_SBC_1	0.25
p.R325K	TCGA-V5-A7RE	ESCA	TCGA	VESSS	DEG_SPOP_SBC_1	0.7237
p.V322I	TCGA-Z2-A8RT	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	0.3056
p.P330T	DO457	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.3611
p.R322G	DO767	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.3056
p.S329F	DO8424	COAD	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.N325K	DO229015	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.6918
p.R327T	DO230961	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	0.7876
p.R327T	DO224594	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	0.7876
p.Q320K	DO26458	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	0.25
p.V324I	DO51301	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	0.7076
p.A314V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VESSS	DEG_SPOP_SBC_1	0.0833
p.A314V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	0.0833
p.S327L	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	0.7667
p.S327L	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	0.7667
p.S327L	NCCIT	testis	COSMIC	VESSS	DEG_SPOP_SBC_1	0.7667
p.S327L	5637	urinary_tract	COSMIC	VESSS	DEG_SPOP_SBC_1	0.7667
p.S327L	JHH-7	liver	COSMIC	VESSS	DEG_SPOP_SBC_1	0.7667
p.S327L	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	0.7667
p.S327L	DSH1	urinary_tract	COSMIC	VESSS	DEG_SPOP_SBC_1	0.7667
p.D321E	HSC-2	upper_aerodigestive_tract	COSMIC	VESSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	764:768	VESSS	SPOP	0.9922	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	556:560	VESSS	SPOP	0.9969	More...
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SPOP_SBC_1	361:365	VESSS	SPOP	0.9641	More...
Q58EX7	Puratrophin-1	DEG_SPOP_SBC_1	87:91	VESSS	SPOP	0.97	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	327:331	VESSS	SPOP	0.9989	More...
Q86XP1	Diacylglycerol kinase eta	DEG_SPOP_SBC_1	584:588	VESSS	SPOP	0.7501	More...
Q8N108	Mesoderm induction early response protein 1	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.7443	More...
Q8N5B7	Ceramide synthase 5	DEG_SPOP_SBC_1	352:356	VESSS	SPOP	0.6322	More...
Q8NEM8	Cytosolic carboxypeptidase 3	DEG_SPOP_SBC_1	611:615	VESSS	SPOP	0.7484	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	69:73	VESSS	SPOP	0.5048	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.5869	More...
Q9P272	Probable tRNA methyltransferase 9B	DEG_SPOP_SBC_1	313:317	VESSS	SPOP	0.7748	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	18:22	VESSS	SPOP	0.9939	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	323:327	VESSS	SPOP	0.5806	More...
Q9H158	Protocadherin alpha-C1	DEG_SPOP_SBC_1	500:504	VESSS	SPOP	0.5524	More...
Q5TG30	Rho GTPase-activating protein 40	DEG_SPOP_SBC_1	24:28	VESSS	SPOP	0.9601	More...
Q8NDA8	Maestro heat-like repeat-containing protein family member 1	DEG_SPOP_SBC_1	321:325	VESSS	SPOP	0.5715	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	71:75	VESSS	SPOP	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESSS

Degron related mutations and impact score

Drug responses associated with PROCA1 mutations

All proteins holding degron of VESSS