DegronMD - Q9UHY1(NRBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T38A	TCGA-13-1499	OV	TCGA	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.3056
p.T38A	DO31563	OV	ICGC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.3056
p.E47K	TCGA-23-2641	OV	TCGA	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.E47K	DO31574	OV	ICGC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.P423H	TCGA-AA-3663	COAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1667
p.P423H	DO9346	COAD	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1667
p.V30A	TCGA-AA-3680	COAD	TCGA	VESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.V30A	TCGA-AA-3680	COAD	TCGA	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.25
p.V30A	DO9980	COAD	ICGC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.V30A	DO9980	COAD	ICGC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.25
p.V444A	TCGA-AM-5821	COAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.0833
p.T8S	TCGA-AP-A059	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.5
p.T8S	DO41361	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.5
p.S21L	TCGA-AX-A2H2	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7667
p.S21L	DO41959	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7667
p.T421I	TCGA-B0-4842	KIRC	TCGA	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1111
p.T421I	DO19238	KIRC	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1111
p.P426S	TCGA-CV-7248	HNSC	TCGA	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.25
p.P426S	DO14806	HNSC	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.25
p.P426S	DO229177	LMS	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.25
p.S11N	TCGA-D1-A167	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.5833
p.S11N	DO40978	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.5833
p.E45D	TCGA-G3-A3CG	LIHC	TCGA	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1111
p.E45D	DO22845	LIHC	ICGC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1111
p.T421A	TCGA-G4-6588	COAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1111
p.T421A	DO10140	COAD	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1111
p.V424A	TCGA-HU-A4GH	STAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1944
p.V424A	DO47743	STAD	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1944
p.S36F	DO217865	BRCA	ICGC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.9093
p.P33S	DO234312	ESAD	ICGC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.6752
p.S20C	DO218030	GACA	ICGC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7541
p.V425L	DO228823	LICA	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.2222
p.A41S	DO228971	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2222
p.S11I	DO229019	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.5833
p.R442C	DO222875	MELA	ICGC	VKTPTPE	DEG_SCF_FBW7_2	429:435	Mutation rewiring degron network	0.1389
p.S23L	SIDM00845	Burkitt's Lymphoma	GDSC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.3056
p.S23L	SIDM00845	Burkitt's Lymphoma	GDSC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.L27P	SIDM01609	Endometrial Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1944
p.L27P	SIDM01609	Endometrial Carcinoma	GDSC	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.L27P	ACH-000972	Endometrial/Uterine Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1944
p.L27P	ACH-000972	Endometrial/Uterine Cancer	CCLE	PVTST	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.S20F	ACH-001982	Metastasis	CCLE	VESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7982
p.S14A	ACH-002025	Colon/Colorectal Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for NRBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRBP1

UniProt ID: Q9UHY1

Entrez ID: 29959

Protein name: Nuclear receptor-binding protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRBP1 in