DegronMD

Uniprot ID: Q9UHY1

Source protein: Nuclear receptor-binding protein

Source gene: NRBP1

Class: DEG_SCF_FBW7_2

Location: 429:435

E3 ligase: FBXW7

DEGRON score: 0.7284

ASA_SCORE: 104.2429

COIL: 0.9661

CONS_SCORE: 0.5942

DSS_SCORE: 0.5872

HELIX: 0.0133

FCONS_SCORE: 1.0589

RIG_SCORE: 0.625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P423H	TCGA-AA-3663	COAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	0.1667
p.P423H	DO9346	COAD	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.1667
p.V444A	TCGA-AM-5821	COAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	0.0833
p.T421I	TCGA-B0-4842	KIRC	TCGA	VKTPTPE	DEG_SCF_FBW7_2	0.1111
p.T421I	DO19238	KIRC	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.1111
p.P426S	TCGA-CV-7248	HNSC	TCGA	VKTPTPE	DEG_SCF_FBW7_2	0.25
p.P426S	DO14806	HNSC	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.25
p.P426S	DO229177	LMS	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.25
p.T421A	TCGA-G4-6588	COAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	0.1111
p.T421A	DO10140	COAD	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.1111
p.V424A	TCGA-HU-A4GH	STAD	TCGA	VKTPTPE	DEG_SCF_FBW7_2	0.1944
p.V424A	DO47743	STAD	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.1944
p.V425L	DO228823	LICA	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.2222
p.R442C	DO222875	MELA	ICGC	VKTPTPE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHY1	Nuclear receptor-binding protein	DEG_SCF_FBW7_2	429:435	VKTPTPE	FBXW7	0.7284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons