DegronMD - Q6ZW76(ANKS3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E338V	TCGA-06-5416	GBM	TCGA	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.E338V	TCGA-06-5416	GBM	TCGA	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0556
p.T319A	TCGA-33-4583	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	327:331	Mutation blocking phosphorylation signal	0.5556
p.R325W	TCGA-B5-A3FC	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2778
p.Q361H	TCGA-BF-A1PZ	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.S332N	TCGA-EO-A22S	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.3056
p.V348I	TCGA-EO-A3B0	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7076
p.D334G	DO222427	BTCA	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.25
p.D323N	DO219723	CESC	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.D323N	DO223910	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.D323N	DO41331	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.A360T	DO230343	COCA	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.A360T	DO41452	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.D321E	DO229022	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1667
p.T341K	DO229006	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.T341K	DO229006	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.L330R	DO45259	LIRI	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.8428
p.A352G	DO23711	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.754
p.I340L	DO51274	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.I340L	DO51274	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.R361H	DO51776	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.R361C	DO222335	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.R361C	DO40996	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.E337V	DO42312	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1667
p.I322M	SIDM00506	Small Cell Lung Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.I322M	ACH-000508	Lung Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.I322M	COR-L88	lung	COSMIC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.V348G	SIDM01660	Kidney Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7532
p.V348G	ACH-000709	Kidney Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7532
p.F341L	SIDM01518	Oral Cavity Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.F341L	SIDM01518	Oral Cavity Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.F341L	ACH-000771	Head and Neck Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.F341L	ACH-000771	Head and Neck Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.L357P	ACH-000801	Skin Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.T333I	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2778
p.W327R	HCT-15	large intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.8634
p.M318V	NCI-H1975	lung	COSMIC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0833
p.Y335H	CCK-81	large intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.T350S	LS-180	large intestine	COSMIC	VQSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKS3

UniProt ID: Q6ZW76

Entrez ID: 124401

Protein name: Ankyrin repeat and SAM domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKS3 in