DegronMD

Uniprot ID: Q6ZW76

Source protein: Ankyrin repeat and SAM domain-containing protein 3

Source gene: ANKS3

Class: DEG_SPOP_SBC_1

Location: 327:331

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 68.62

COIL: 0.8696

CONS_SCORE: 0.6572

DSS_SCORE: 0.6602

HELIX: 0.0796

FCONS_SCORE: 1.3538

RIG_SCORE: 0.6248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E338V	TCGA-06-5416	GBM	TCGA	VESSS	DEG_SPOP_SBC_1	0.1389
p.T319A	TCGA-33-4583	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	0.5556
p.R325W	TCGA-B5-A3FC	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.2778
p.S332N	TCGA-EO-A22S	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.3056
p.D334G	DO222427	BTCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.25
p.D323N	DO219723	CESC	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.D323N	DO223910	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.D323N	DO41331	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.D321E	DO229022	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.1667
p.T341K	DO229006	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.0556
p.L330R	DO45259	LIRI	ICGC	VESSS	DEG_SPOP_SBC_1	0.8428
p.I340L	DO51274	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	0.0833
p.E337V	DO42312	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.1667
p.I322M	SIDM00506	Small Cell Lung Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.1944
p.I322M	ACH-000508	Lung Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.1944
p.I322M	COR-L88	lung	COSMIC	VESSS	DEG_SPOP_SBC_1	0.1944
p.F341L	SIDM01518	Oral Cavity Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.0556
p.F341L	ACH-000771	Head and Neck Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.0556
p.T333I	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	0.2778
p.W327R	HCT-15	large_intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	0.8634
p.M318V	NCI-H1975	lung	COSMIC	VESSS	DEG_SPOP_SBC_1	0.0833
p.Y335H	CCK-81	large_intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	764:768	VESSS	SPOP	0.9922	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	556:560	VESSS	SPOP	0.9969	More...
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SPOP_SBC_1	361:365	VESSS	SPOP	0.9641	More...
Q58EX7	Puratrophin-1	DEG_SPOP_SBC_1	87:91	VESSS	SPOP	0.97	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	327:331	VESSS	SPOP	0.9989	More...
Q86XP1	Diacylglycerol kinase eta	DEG_SPOP_SBC_1	584:588	VESSS	SPOP	0.7501	More...
Q8N108	Mesoderm induction early response protein 1	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.7443	More...
Q8N5B7	Ceramide synthase 5	DEG_SPOP_SBC_1	352:356	VESSS	SPOP	0.6322	More...
Q8NEM8	Cytosolic carboxypeptidase 3	DEG_SPOP_SBC_1	611:615	VESSS	SPOP	0.7484	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	69:73	VESSS	SPOP	0.5048	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.5869	More...
Q9P272	Probable tRNA methyltransferase 9B	DEG_SPOP_SBC_1	313:317	VESSS	SPOP	0.7748	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	18:22	VESSS	SPOP	0.9939	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	323:327	VESSS	SPOP	0.5806	More...
Q9H158	Protocadherin alpha-C1	DEG_SPOP_SBC_1	500:504	VESSS	SPOP	0.5524	More...
Q5TG30	Rho GTPase-activating protein 40	DEG_SPOP_SBC_1	24:28	VESSS	SPOP	0.9601	More...
Q8NDA8	Maestro heat-like repeat-containing protein family member 1	DEG_SPOP_SBC_1	321:325	VESSS	SPOP	0.5715	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	71:75	VESSS	SPOP	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESSS

Degron related mutations and impact score

Drug responses associated with ANKS3 mutations

All proteins holding degron of VESSS