DegronMD - Q8NDA8(MROH1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S324A	TCGA-A5-A1OF	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.7588
p.S324A	DO42568	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.7588
p.Q316R	TCGA-D1-A17Q	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1944
p.Q316R	DO41903	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1944
p.K333N	TCGA-EM-A2CN	THCA	TCGA	VESSS	DEG_SPOP_SBC_1	321:325	Mutation substituting flanking lysine	0.2222
p.K333N	DO39886	THCA	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation substituting flanking lysine	0.2222
p.M329I	TCGA-NC-A5HR	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.M329I	DO219203	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.A312V	DO233745	GACA	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0833
p.A311S	DO228985	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.V319L	DO229026	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2778
p.N331K	DO44846	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.N331Y	DO44846	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.L327M	DO38404	STAD	ICGC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2778
p.E322V	SIDM00582	Pancreatic Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.6582
p.E322V	ACH-000281	Pancreatic Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.6582
p.E322V	KP-2	pancreas	COSMIC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.6582
p.P320L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.3056
p.P320L	ACH-000414	Lung Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.3056
p.P320L	NCI-H1944	lung	COSMIC	VESSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MROH1

UniProt ID: Q8NDA8

Entrez ID: 727957

Protein name: Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MROH1 in