DegronMD

Uniprot ID: Q8NDA8

Source protein: Maestro heat-like repeat-containing protein family member 1

Source gene: MROH1

Class: DEG_SPOP_SBC_1

Location: 321:325

E3 ligase: SPOP

DEGRON score: 0.5715

ASA_SCORE: 76.98

COIL: 0.8718

CONS_SCORE: 0.328

DSS_SCORE: 0.1816

HELIX: 0.0942

FCONS_SCORE: 0.7654

RIG_SCORE: 0.7502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S324A	TCGA-A5-A1OF	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.7588
p.S324A	DO42568	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.7588
p.Q316R	TCGA-D1-A17Q	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.1944
p.Q316R	DO41903	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.1944
p.K333N	TCGA-EM-A2CN	THCA	TCGA	VESSS	DEG_SPOP_SBC_1	0.2222
p.K333N	DO39886	THCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.M329I	TCGA-NC-A5HR	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	0.2222
p.M329I	DO219203	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.A312V	DO233745	GACA	ICGC	VESSS	DEG_SPOP_SBC_1	0.0833
p.A311S	DO228985	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.0556
p.V319L	DO229026	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.N331K	DO44846	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.1667
p.N331Y	DO44846	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.1667
p.L327M	DO38404	STAD	ICGC	VESSS	DEG_SPOP_SBC_1	0.2778
p.E322V	SIDM00582	Pancreatic Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.6582
p.E322V	ACH-000281	Pancreatic Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.6582
p.E322V	KP-2	pancreas	COSMIC	VESSS	DEG_SPOP_SBC_1	0.6582
p.P320L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.3056
p.P320L	ACH-000414	Lung Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.3056
p.P320L	NCI-H1944	lung	COSMIC	VESSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	764:768	VESSS	SPOP	0.9922	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	556:560	VESSS	SPOP	0.9969	More...
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SPOP_SBC_1	361:365	VESSS	SPOP	0.9641	More...
Q58EX7	Puratrophin-1	DEG_SPOP_SBC_1	87:91	VESSS	SPOP	0.97	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	327:331	VESSS	SPOP	0.9989	More...
Q86XP1	Diacylglycerol kinase eta	DEG_SPOP_SBC_1	584:588	VESSS	SPOP	0.7501	More...
Q8N108	Mesoderm induction early response protein 1	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.7443	More...
Q8N5B7	Ceramide synthase 5	DEG_SPOP_SBC_1	352:356	VESSS	SPOP	0.6322	More...
Q8NEM8	Cytosolic carboxypeptidase 3	DEG_SPOP_SBC_1	611:615	VESSS	SPOP	0.7484	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	69:73	VESSS	SPOP	0.5048	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.5869	More...
Q9P272	Probable tRNA methyltransferase 9B	DEG_SPOP_SBC_1	313:317	VESSS	SPOP	0.7748	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	18:22	VESSS	SPOP	0.9939	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	323:327	VESSS	SPOP	0.5806	More...
Q9H158	Protocadherin alpha-C1	DEG_SPOP_SBC_1	500:504	VESSS	SPOP	0.5524	More...
Q5TG30	Rho GTPase-activating protein 40	DEG_SPOP_SBC_1	24:28	VESSS	SPOP	0.9601	More...
Q8NDA8	Maestro heat-like repeat-containing protein family member 1	DEG_SPOP_SBC_1	321:325	VESSS	SPOP	0.5715	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	71:75	VESSS	SPOP	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESSS

Degron related mutations and impact score

Drug responses associated with MROH1 mutations

All proteins holding degron of VESSS