DegronMD

Uniprot ID: Q8NFG4

Source protein: Folliculin

Source gene: FLCN

Class: DEG_SPOP_SBC_1

Location: 69:73

E3 ligase: SPOP

DEGRON score: 0.5048

ASA_SCORE: 82.86

COIL: 0.8838

CONS_SCORE: 0.3424

DSS_SCORE: 0.7163

HELIX: 0.063

FCONS_SCORE: 0.9109

RIG_SCORE: 0.5373

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S73I	TCGA-55-8511	LUAD	TCGA	VESSS	DEG_SPOP_SBC_1	0.8453
p.S73I	DO24940	LUAD	ICGC	VESSS	DEG_SPOP_SBC_1	0.8453
p.E70K	TCGA-BS-A0UV	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.591
p.E70K	DO42793	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.591
p.E65Q	TCGA-C5-A1M7	CESC	TCGA	VESSS	DEG_SPOP_SBC_1	0.2222
p.E65Q	DO48981	CESC	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.S62I	TCGA-DK-AA76	BLCA	TCGA	VESSS	DEG_SPOP_SBC_1	0.5833
p.S62I	DO219013	BLCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.5833
p.D80N	TCGA-ER-A19W	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	0.1389
p.D80N	DO50300	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	0.1389
p.S62R	TCGA-OR-A5L3	ACC	TCGA	VESSS	DEG_SPOP_SBC_1	0.5833
p.P76T	DO229018	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.25
p.A60E	DO229022	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.0833
p.H61R	DO231782	LINC	ICGC	VESSS	DEG_SPOP_SBC_1	0.1111
p.A60V	SIDM00960	Colorectal Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.0833
p.A60V	ACH-000798	Colon/Colorectal Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.0833
p.A60V	CL-40	large_intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	0.0833
p.A64V	SIDM01080	Oral Cavity Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.1944
p.A64V	ACH-000181	Head and Neck Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.1944
p.A64V	SCC-9	upper_aerodigestive_tract	COSMIC	VESSS	DEG_SPOP_SBC_1	0.1944
p.A67T	SIDM00333	Endometrial Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.2778
p.A67T	ACH-000988	Endometrial/Uterine Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.2778
p.A67T	MFE-319	endometrium	COSMIC	VESSS	DEG_SPOP_SBC_1	0.2778
p.S62G	SIDM00333	Endometrial Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.5833
p.S62G	ACH-000988	Endometrial/Uterine Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.5833
p.S62G	MFE-319	endometrium	COSMIC	VESSS	DEG_SPOP_SBC_1	0.5833
p.P74L	SIDM00217	Colorectal Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.3056
p.P74L	ACH-000999	Colon/Colorectal Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.3056
p.P74L	SNU-1040	large_intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	764:768	VESSS	SPOP	0.9922	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	556:560	VESSS	SPOP	0.9969	More...
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SPOP_SBC_1	361:365	VESSS	SPOP	0.9641	More...
Q58EX7	Puratrophin-1	DEG_SPOP_SBC_1	87:91	VESSS	SPOP	0.97	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	327:331	VESSS	SPOP	0.9989	More...
Q86XP1	Diacylglycerol kinase eta	DEG_SPOP_SBC_1	584:588	VESSS	SPOP	0.7501	More...
Q8N108	Mesoderm induction early response protein 1	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.7443	More...
Q8N5B7	Ceramide synthase 5	DEG_SPOP_SBC_1	352:356	VESSS	SPOP	0.6322	More...
Q8NEM8	Cytosolic carboxypeptidase 3	DEG_SPOP_SBC_1	611:615	VESSS	SPOP	0.7484	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	69:73	VESSS	SPOP	0.5048	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.5869	More...
Q9P272	Probable tRNA methyltransferase 9B	DEG_SPOP_SBC_1	313:317	VESSS	SPOP	0.7748	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	18:22	VESSS	SPOP	0.9939	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	323:327	VESSS	SPOP	0.5806	More...
Q9H158	Protocadherin alpha-C1	DEG_SPOP_SBC_1	500:504	VESSS	SPOP	0.5524	More...
Q5TG30	Rho GTPase-activating protein 40	DEG_SPOP_SBC_1	24:28	VESSS	SPOP	0.9601	More...
Q8NDA8	Maestro heat-like repeat-containing protein family member 1	DEG_SPOP_SBC_1	321:325	VESSS	SPOP	0.5715	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	71:75	VESSS	SPOP	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESSS

Degron related mutations and impact score

Drug responses associated with FLCN mutations

All proteins holding degron of VESSS