DegronMD

Uniprot ID: Q8NEM8

Source protein: Cytosolic carboxypeptidase 3

Source gene: AGBL3

Class: DEG_SPOP_SBC_1

Location: 611:615

E3 ligase: SPOP

DEGRON score: 0.7484

ASA_SCORE: 72.46

COIL: 0.728

CONS_SCORE: 0.3696

DSS_SCORE: 0.4354

HELIX: 0.2346

FCONS_SCORE: 0.979

RIG_SCORE: 0.7061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R616Q	TCGA-AP-A059	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.3056
p.R616Q	DO41361	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.3056
p.E612K	TCGA-GS-A9TW	DLBC	TCGA	VESSS	DEG_SPOP_SBC_1	0.591
p.E612K	DO219915	DLBC	ICGC	VESSS	DEG_SPOP_SBC_1	0.591
p.D606E	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.1944
p.D606E	ACH-000664	Lymphoma	CCLE	VESSS	DEG_SPOP_SBC_1	0.1944
p.D606E	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	0.1944
p.D625N	ACH-000729	Lung Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	764:768	VESSS	SPOP	0.9922	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	556:560	VESSS	SPOP	0.9969	More...
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SPOP_SBC_1	361:365	VESSS	SPOP	0.9641	More...
Q58EX7	Puratrophin-1	DEG_SPOP_SBC_1	87:91	VESSS	SPOP	0.97	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	327:331	VESSS	SPOP	0.9989	More...
Q86XP1	Diacylglycerol kinase eta	DEG_SPOP_SBC_1	584:588	VESSS	SPOP	0.7501	More...
Q8N108	Mesoderm induction early response protein 1	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.7443	More...
Q8N5B7	Ceramide synthase 5	DEG_SPOP_SBC_1	352:356	VESSS	SPOP	0.6322	More...
Q8NEM8	Cytosolic carboxypeptidase 3	DEG_SPOP_SBC_1	611:615	VESSS	SPOP	0.7484	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	69:73	VESSS	SPOP	0.5048	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.5869	More...
Q9P272	Probable tRNA methyltransferase 9B	DEG_SPOP_SBC_1	313:317	VESSS	SPOP	0.7748	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	18:22	VESSS	SPOP	0.9939	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	323:327	VESSS	SPOP	0.5806	More...
Q9H158	Protocadherin alpha-C1	DEG_SPOP_SBC_1	500:504	VESSS	SPOP	0.5524	More...
Q5TG30	Rho GTPase-activating protein 40	DEG_SPOP_SBC_1	24:28	VESSS	SPOP	0.9601	More...
Q8NDA8	Maestro heat-like repeat-containing protein family member 1	DEG_SPOP_SBC_1	321:325	VESSS	SPOP	0.5715	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	71:75	VESSS	SPOP	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESSS

Degron related mutations and impact score

Drug responses associated with AGBL3 mutations

All proteins holding degron of VESSS