DegronMD - Q58EX7(PLEKHG4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R945H	TCGA-2W-A8YY	CESC	TCGA	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation altering degron motif	0.8244
p.R945H	DO223732	CESC	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation altering degron motif	0.8244
p.P99S	TCGA-61-2113	OV	TCGA	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1111
p.P99S	DO29328	OV	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1111
p.P99R	TCGA-61-2113	OV	TCGA	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1111
p.P99R	DO29328	OV	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1111
p.Q83H	TCGA-66-2785	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.Q83H	DO26520	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.R939C	TCGA-BH-A18S	BRCA	TCGA	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1389
p.R939C	TCGA-BH-A18S	BRCA	TCGA	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.1667
p.R936C	TCGA-BR-4368	STAD	TCGA	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.0556
p.R936C	TCGA-BR-4368	STAD	TCGA	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.0833
p.R936C	DO38715	STAD	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.0556
p.R936C	DO38715	STAD	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.0833
p.V92L	TCGA-CG-5733	STAD	TCGA	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.V92L	DO38551	STAD	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.S79L	TCGA-GN-A268	SKCM	TCGA	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1111
p.S79L	DO37477	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1111
p.S90C	TCGA-VS-A94X	CESC	TCGA	VESSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.7541
p.S90C	DO51632	CESC	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.7541
p.D77Y	TCGA-WK-A8XX	SARC	TCGA	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0556
p.D77Y	DO220300	SARC	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0556
p.R944C	DO230309	COCA	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.2778
p.R944C	DO230309	COCA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.3056
p.R959H	DO233884	GACA	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1111
p.R959H	DO233884	GACA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.1111
p.V943L	DO228976	LICA	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.25
p.V943L	DO228976	LICA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.2778
p.A958S	DO229015	LICA	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1389
p.A958S	DO229015	LICA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.1389
p.Q948L	DO24140	LUAD	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation altering degron motif	0.7765
p.Q948L	DO24140	LUAD	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation altering degron motif	0.7765
p.S942F	DO220900	MELA	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.2222
p.S942F	DO220900	MELA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.25
p.D81N	DO220902	MELA	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1667
p.G96R	DO233458	PRAD	ICGC	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.R956C	DO223286	UCEC	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1944
p.R956C	DO223286	UCEC	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.1944
p.R956C	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1944
p.R956C	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.1944
p.R956H	DO52402	UCEC	ICGC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1944
p.R956H	DO52402	UCEC	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.1944
p.R936H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.0556
p.R936H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.0833
p.F949L	SIDM00760	Small Cell Lung Carcinoma	GDSC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation altering degron motif	0.6981
p.F949L	SIDM00760	Small Cell Lung Carcinoma	GDSC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation altering degron motif	0.6981
p.F949L	ACH-000729	Lung Cancer	CCLE	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation altering degron motif	0.6981
p.F949L	ACH-000729	Lung Cancer	CCLE	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation altering degron motif	0.6981
p.F949L	NCI-H1963	lung	COSMIC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation altering degron motif	0.6981
p.F949L	NCI-H1963	lung	COSMIC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation altering degron motif	0.6981
p.L93Q	ACH-001510	Head and Neck Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.A939T	SK-UT-1	soft tissue	COSMIC	IFLFEE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1389
p.A939T	SK-UT-1	soft tissue	COSMIC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	945:951	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHG4

UniProt ID: Q58EX7

Entrez ID: 25894

Protein name: Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHG4 in