DegronMD

Uniprot ID: Q58EX7

Source protein: Puratrophin-1

Source gene: PLEKHG4

Class: LIG_APCC_ABBA_1

Location: 946:951

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6528

ASA_SCORE: 38.3333

COIL: 0.3808

CONS_SCORE: 0.8472

DSS_SCORE: 0.0624

HELIX: 0.031

FCONS_SCORE: 1.5394

RIG_SCORE: 0.9561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R939C	TCGA-BH-A18S	BRCA	TCGA	IFLFEE	LIG_APCC_ABBA_1	0.1389
p.R936C	TCGA-BR-4368	STAD	TCGA	IFLFEE	LIG_APCC_ABBA_1	0.0556
p.R936C	DO38715	STAD	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.0556
p.R944C	DO230309	COCA	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.2778
p.R959H	DO233884	GACA	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.1111
p.V943L	DO228976	LICA	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.25
p.A958S	DO229015	LICA	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.1389
p.Q948L	DO24140	LUAD	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.7765
p.S942F	DO220900	MELA	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.2222
p.R956C	DO223286	UCEC	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.1944
p.R956C	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	IFLFEE	LIG_APCC_ABBA_1	0.1944
p.R956H	DO52402	UCEC	ICGC	IFLFEE	LIG_APCC_ABBA_1	0.1944
p.R936H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	IFLFEE	LIG_APCC_ABBA_1	0.0556
p.F949L	SIDM00760	Small Cell Lung Carcinoma	GDSC	IFLFEE	LIG_APCC_ABBA_1	0.6981
p.F949L	ACH-000729	Lung Cancer	CCLE	IFLFEE	LIG_APCC_ABBA_1	0.6981
p.F949L	NCI-H1963	lung	COSMIC	IFLFEE	LIG_APCC_ABBA_1	0.6981
p.A939T	SK-UT-1	soft_tissue	COSMIC	IFLFEE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58EX7	Puratrophin-1	LIG_APCC_ABBA_1	946:951	IFLFEE	APC,CDC20,FZR1	0.6528	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons