DegronMD

Uniprot ID: Q58EX7

Source protein: Puratrophin-1

Source gene: PLEKHG4

Class: LIG_APCC_ABBAyCdc20_2

Location: 945:951

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7077

ASA_SCORE: 43.3

COIL: 0.3371

CONS_SCORE: 0.7912

DSS_SCORE: 0.0587

HELIX: 0.0271

FCONS_SCORE: 1.4375

RIG_SCORE: 0.952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R945H	TCGA-2W-A8YY	CESC	TCGA	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R945H	DO223732	CESC	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R939C	TCGA-BH-A18S	BRCA	TCGA	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R936C	TCGA-BR-4368	STAD	TCGA	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R936C	DO38715	STAD	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R944C	DO230309	COCA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R959H	DO233884	GACA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V943L	DO228976	LICA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A958S	DO229015	LICA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q948L	DO24140	LUAD	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.7765
p.S942F	DO220900	MELA	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.25
p.R956C	DO223286	UCEC	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R956C	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R956H	DO52402	UCEC	ICGC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R936H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.F949L	SIDM00760	Small Cell Lung Carcinoma	GDSC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.6981
p.F949L	ACH-000729	Lung Cancer	CCLE	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.6981
p.F949L	NCI-H1963	lung	COSMIC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.6981
p.A939T	SK-UT-1	soft_tissue	COSMIC	RIFLFEE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58EX7	Puratrophin-1	LIG_APCC_ABBAyCdc20_2	945:951	RIFLFEE	APC,CDC20,FZR1	0.7077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons