DegronMD - Q16236(NFE2L2)

FUNCTION: Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Plays also an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. View more >>

GO - Biological processes (BP): aflatoxin catabolic process [GO:0046223]; aging [GO:0007568]; cell redox homeostasis [GO:0045454]; cellular response to angiotensin [GO:1904385]; cellular response to copper ion [GO:0071280]; cellular response to fluid shear stress [GO:0071498]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to oxidative stress [GO:0034599]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; endoplasmic reticulum unfolded protein response [GO:0030968]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glutathione biosynthetic process [GO:1903788]; positive regulation of neuron projection development [GO:0010976]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0036091]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of embryonic development [GO:0045995]; regulation of innate immune response [GO:0045088]; regulation of removal of superoxide radicals [GO:2000121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lithium ion [GO:0010226] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G412V	TCGA-17-Z015	LUAD	TCGA	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.0833
p.D27H	TCGA-17-Z026	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D27H	TCGA-34-2608	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.Q26R	TCGA-17-Z033	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7329
p.Q26R	TCGA-33-A4WN	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7329
p.R34G	TCGA-18-3411	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-63-A5ML	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-77-6843	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-85-8049	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-94-7943	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-A5-A0R8	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-AJ-A5DV	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-AJ-A8CV	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-AX-A05W	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-B5-A0JT	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-CR-7383	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-DK-AA6Q	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-E5-A2PC	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-EY-A1H0	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-FI-A2D4	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-G2-A3IB	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-GU-AATQ	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-LN-A49R	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-NC-A5HR	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	TCGA-XF-AAN3	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	SIDM00182	Head and Neck Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34G	LB771-HNC	upper aerodigestive tract	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.G31A	TCGA-18-3415	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	TCGA-22-5483	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	TCGA-66-2766	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	TCGA-68-A59J	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	TCGA-85-A4CL	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	TCGA-DK-A1AE	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	TCGA-LN-A7HW	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	SIDM00820	Kidney Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	RCC-ER	kidney	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.G31A	NCI-H2228	lung	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.754
p.R34Q	TCGA-18-4721	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34Q	TCGA-22-5477	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34Q	TCGA-66-2795	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34Q	TCGA-96-7545	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34Q	TCGA-AX-A2HC	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34Q	TCGA-JW-A852	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34Q	TCGA-LA-A446	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34Q	ACH-000690	Lung Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.D77G	TCGA-18-5592	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7198
p.T80K	TCGA-21-1071	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7306
p.T80K	TCGA-56-A4BY	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7306
p.T80K	TCGA-B1-A47M	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7306
p.D29H	TCGA-21-1075	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-22-4605	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-34-5240	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-46-3768	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-78-8660	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-92-7341	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-B5-A11R	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-C5-A1MN	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-CV-6951	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-CV-7424	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-CZ-5456	KIRC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-DS-A0VM	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-P3-A6T4	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-VR-A8ER	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-XF-A9SY	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	TCGA-YC-A9TC	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	SIDM01520	Oral Cavity Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.D29H	RERF-LC-Sq1	lung	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7688
p.L370V	TCGA-22-4594	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.Q26P	TCGA-22-5473	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7035
p.Q26P	TCGA-DD-A4NI	LIHC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7035
p.Q26P	SIDM00506	Small Cell Lung Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7035
p.Q26P	COR-L88	lung	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7035
p.E79Q	TCGA-22-5474	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-39-5022	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-56-5897	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-66-2770	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-85-7696	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-85-8052	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-94-A5I6	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-CV-6940	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-CV-7177	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-FD-A3SM	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-H7-7774	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-LN-A4MR	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-LN-A7HZ	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E79Q	TCGA-ZJ-AAXJ	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.R34P	TCGA-22-5479	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34P	TCGA-33-A5GW	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34P	TCGA-34-5236	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34P	TCGA-68-7755	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34P	TCGA-98-A53I	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34P	TCGA-CN-4723	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34P	TCGA-K4-A5RI	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.R34P	SIDM01612	Endometrial Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.D29Y	TCGA-33-4586	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7325
p.D29Y	TCGA-63-A5MJ	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7325
p.D29Y	TCGA-FD-A3N6	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7325
p.D29Y	TCGA-IQ-A61H	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7325
p.D29Y	TCGA-JX-A3Q0	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7325
p.D29N	TCGA-33-4589	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6932
p.D29N	TCGA-33-AAS8	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6932
p.D29N	TCGA-56-8629	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6932
p.D29N	TCGA-58-A46K	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6932
p.D29N	TCGA-66-2783	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6932
p.D29G	TCGA-34-2596	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7198
p.D29G	TCGA-52-7812	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7198
p.D29G	TCGA-62-8395	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7198
p.D29G	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7198
p.D29G	TE-11	oesophagus	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7198
p.W24C	TCGA-34-2608	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.W24C	TCGA-56-7582	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.W24C	TCGA-CV-6935	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.W24C	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.W24C	KYSE-70	oesophagus	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.Q26L	TCGA-37-4135	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7765
p.L30F	TCGA-46-3765	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6981
p.L30F	TCGA-51-4081	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6981
p.L30F	TCGA-68-7756	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6981
p.L30F	TCGA-77-A5GF	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6981
p.L30F	TCGA-H7-7774	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6981
p.L30F	TCGA-IG-A625	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6981
p.E82D	TCGA-4A-A93X	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-55-6975	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-A5-A0G9	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-B2-4098	KIRC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-BG-A0MK	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-BK-A0C9	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-BS-A0U7	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-D1-A1O7	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-DD-A39V	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-DS-A0VK	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-EY-A1H0	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-FD-A3SM	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-VS-A8EH	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	TCGA-ZH-A8Y2	CHOL	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	SIDM00591	Oral Cavity Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.E82D	HO-1-u-1	upper aerodigestive tract	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6758
p.S414N	TCGA-50-5930	LUAD	TCGA	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.1389
p.S414N	SIDM00193	Colorectal Carcinoma	GDSC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.1389
p.S414N	SNU-81	large intestine	COSMIC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.1389
p.G81V	TCGA-51-4079	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7532
p.G81V	TCGA-BG-A0M4	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7532
p.G81V	TCGA-BQ-7051	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7532
p.G81V	TCGA-LN-A4MQ	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7532
p.T80A	TCGA-52-7622	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7139
p.T80A	TCGA-UF-A71B	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7139
p.R34L	TCGA-52-7812	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.G31R	TCGA-55-A48Y	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7568
p.G31R	TCGA-BT-A20U	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7568
p.G31R	SIDM00596	Endometrial Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7568
p.G31R	HEC-1	endometrium	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7568
p.T80I	TCGA-5R-AAAM	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7078
p.T80I	TCGA-FD-A5BU	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7078
p.T80I	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7078
p.T80I	KYSE-520	oesophagus	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7078
p.G81S	TCGA-60-2709	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	TCGA-66-2787	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	TCGA-EO-A22T	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	TCGA-LN-A8I0	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	TCGA-QS-A5YR	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	SIDM00174	Head and Neck Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	SIDM01624	Bladder Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	SIDM01529	Bladder Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	BB49-HNC	upper aerodigestive tract	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.G81S	OE21	oesophagus	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.A384V	TCGA-62-A471	LUAD	TCGA	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0833
p.G31V	TCGA-63-A5MB	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7532
p.M235I	TCGA-63-A5MY	LUSC	TCGA	DNYHFYSSIP	CBL_PTK	224:233	Mutation rewiring degron network	0.2778
p.E67K	TCGA-73-4658	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.0556
p.E79D	TCGA-92-8064	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.5647
p.E79D	TCGA-IR-A3LH	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.5647
p.E79D	DO48751	LIRI	ICGC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.5647
p.E79G	TCGA-92-8064	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7199
p.E79G	TCGA-IG-A50L	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7199
p.W24R	TCGA-93-8067	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.W24R	TCGA-BT-A0YX	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.W24R	TCGA-CQ-A4CG	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.W24R	TCGA-L5-A88Z	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.E79V	TCGA-97-7941	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7693
p.E79V	TCGA-DD-A4NO	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7693
p.E82Q	TCGA-97-8174	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.E82Q	TCGA-Q1-A5R2	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6744
p.T80P	TCGA-A5-A0GP	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7031
p.T80P	TCGA-BK-A0C9	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7031
p.Q26K	TCGA-A5-A0GW	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6944
p.G81D	TCGA-A7-A26E	BRCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7198
p.G81D	TCGA-B0-5097	KIRC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7198
p.G81C	TCGA-AJ-A2QO	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.76
p.G81C	TCGA-CV-7429	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.76
p.G81C	TCGA-DD-AADJ	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.76
p.F39S	TCGA-AX-A06F	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1389
p.D16Y	TCGA-AX-A2HC	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.0556
p.D38V	TCGA-B5-A3FC	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1667
p.E79K	TCGA-BL-A13I	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	TCGA-BT-A42B	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	TCGA-CV-6955	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	TCGA-CV-7099	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	TCGA-HG-A2PA	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	TCGA-IG-A8O2	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	TCGA-J1-A4AH	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	TCGA-P3-A5QF	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	SIDM00625	Other Sarcomas	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	MES-SA	soft tissue	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.E79K	LK-2	lung	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7022
p.L30H	TCGA-BP-5178	KIRC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7313
p.L30H	TCGA-CQ-5324	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7313
p.L30R	TCGA-BQ-5881	KIRP	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.8428
p.E82G	TCGA-BQ-7044	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7199
p.E82G	TCGA-DD-AAC8	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7199
p.E82G	TCGA-LN-A8HZ	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7199
p.P214Q	TCGA-CG-5722	STAD	TCGA	ETTMVPSP	DEG_COP1_1	209:216	Mutation altering degron motif	0.7035
p.V32G	TCGA-CN-6019	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7532
p.I28T	TCGA-CV-7437	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.5966
p.I28T	TCGA-FZ-5924	PAAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.5966
p.T80R	TCGA-D1-A17U	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7876
p.T80R	SIDM00935	Other Solid Cancers	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7876
p.T80R	CAL-39	vulva	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7876
p.G401V	TCGA-DA-A1IB	SKCM	TCGA	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.2778
p.D27Y	TCGA-DD-AAEH	LIHC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7325
p.G81R	TCGA-DD-AAVY	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7568
p.D27N	TCGA-DF-A2KN	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6932
p.D77Y	TCGA-DS-A3LQ	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7325
p.D77Y	TCGA-L3-A524	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7325
p.D77Y	SIDM01248	Thyroid Gland Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7325
p.D77Y	SIDM01162	Kidney Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7325
p.D77Y	SIDM01167	Thyroid Gland Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7325
p.D77Y	CGTH-W-1	thyroid	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7325
p.D77Y	SW156	kidney	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7325
p.P406L	TCGA-EE-A3J5	SKCM	TCGA	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.D77H	TCGA-EK-A2PI	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7688
p.E67D	TCGA-EO-A22U	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.0556
p.E82V	TCGA-FD-A43Y	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7693
p.E82V	TCGA-T3-A92N	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7693
p.G81A	TCGA-G2-AA3C	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.754
p.G81A	TCGA-G3-AAV3	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.754
p.D368H	TCGA-JW-A5VL	CESC	TCGA	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.25
p.E82A	TCGA-LN-A8I1	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7701
p.G31E	TCGA-LN-A9FQ	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7199
p.L30P	TCGA-MT-A67A	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7582
p.V417M	TCGA-UY-A9PE	BLCA	TCGA	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.2222
p.E35D	TCGA-YC-A89H	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.25
p.E19D	DO51948	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1389
p.R18G	DO51896	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO219053	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO219005	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO512	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO702	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO15366	HNSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO23482	LINC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO230982	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO224613	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO231179	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO26890	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO26475	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO26758	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO219151	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO27588	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO219203	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO232037	ORCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO219766	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO219765	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO40802	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO40966	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO43170	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO43114	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	DO42584	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	ACH-002265	Head and Neck Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18G	LB771-HNC	upper aerodigestive tract	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.V394M	DO219043	BLCA	ICGC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.7208
p.R18P	DO219029	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO223009	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO222607	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO14830	HNSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO230535	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO230538	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO26512	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO26572	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO26778	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO27287	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO219122	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	DO219182	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18P	ACH-000946	Endometrial/Uterine Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.K37Q	DO219085	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1944
p.K37Q	DO41752	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1944
p.S81G	DO52615	BOCA	ICGC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.6993
p.D201H	DO224793	BRCA	ICGC	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.1111
p.R18Q	DO49978	CESC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO222645	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO230536	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO224541	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO26894	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO26492	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO26710	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO45450	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO27104	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	DO41572	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18Q	ACH-000593	Bladder Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.L243F	DO49976	CESC	ICGC	DNYHFYSSIP	CBL_PTK	224:233	Mutation blocking phosphorylation signal	0.5
p.L243F	DO231152	LUSC	ICGC	DNYHFYSSIP	CBL_PTK	224:233	Mutation blocking phosphorylation signal	0.5
p.E357Q	DO48986	CESC	ICGC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.T416P	DO227745	COCA	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.1944
p.E29K	DO227844	COCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7022
p.D421N	DO229016	COCA	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation altering degron motif	0.6932
p.E354K	DO234197	ESAD	ICGC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1389
p.S24N	DO222607	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2778
p.A90T	DO233784	GACA	ICGC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.1111
p.R433T	DO49998	HNSC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation blocking phosphorylation signal	0.6389
p.D434G	DO219080	HNSC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.1667
p.V16G	DO14316	HNSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.0556
p.V16G	DO229033	LICA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.0556
p.D239E	DO14166	HNSC	ICGC	DNYHFYSSIP	CBL_PTK	224:233	Mutation rewiring degron network	0.1667
p.T419K	DO228974	LICA	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.2778
p.P386Q	DO229028	LICA	ICGC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.P386T	DO229028	LICA	ICGC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.A84D	DO229031	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2778
p.P370H	DO229035	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.S232R	DO229045	LICA	ICGC	DNYHFYSSIP	CBL_PTK	224:233	Mutation altering degron motif	0.7427
p.I70L	DO44848	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.1389
p.S17R	DO23482	LINC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.0833
p.S391N	DO25189	LUAD	ICGC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.2778
p.S391N	ACH-000991	Colon/Colorectal Cancer	CCLE	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.2778
p.S391N	SNU-81	large intestine	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.2778
p.A361V	DO45347	LUAD	ICGC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.6936
p.R18L	DO224626	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.R18L	DO27067	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.1111
p.S207L	DO231179	LUSC	ICGC	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.2778
p.H91R	DO26436	LUSC	ICGC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.0833
p.M212I	DO219171	LUSC	ICGC	ETTMVPSP	DEG_COP1_1	209:216	Mutation altering degron motif	0.6507
p.S233G	DO51407	PRAD	ICGC	DNYHFYSSIP	CBL_PTK	224:233	Mutation altering degron motif	0.6993
p.H91N	DO37405	SKCM	ICGC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.0833
p.P383L	DO47331	SKCM	ICGC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0556
p.A429T	DO222381	STAD	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation rewiring degron network	0.3056
p.R426H	DO40889	UCEC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation altering degron motif	0.8244
p.R426H	no-10	central nervous system	COSMIC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation altering degron motif	0.8244
p.R27G	DO41002	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7568
p.F23S	DO41752	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.25
p.D22V	DO41871	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2222
p.S425I	DO42568	UCEC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation altering degron motif	0.7341
p.A355T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1667
p.A355T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1667
p.D77V	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7785
p.D77V	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7785
p.D77V	KYSE-180	oesophagus	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7785
p.D77V	EBC-1	lung	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7785
p.P352L	SIDM00007	Other Solid Cancers	GDSC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.P352L	MCC13	skin	COSMIC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.Y366C	SIDM00463	T-Lymphoblastic Leukemia	GDSC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.Y366C	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	VESSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.P233S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DNYHFYSSIP	CBL_PTK	224:233	Mutation altering degron motif	0.6752
p.P233S	SIDM00267	Biliary Tract Carcinoma	GDSC	DNYHFYSSIP	CBL_PTK	224:233	Mutation altering degron motif	0.6752
p.P233S	SIDM00060	Ovarian Carcinoma	GDSC	DNYHFYSSIP	CBL_PTK	224:233	Mutation altering degron motif	0.6752
p.D27A	SIDM00188	Kidney Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7793
p.D27A	HA7-RCC	kidney	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7793
p.Q73H	SIDM01060	Melanoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222
p.Q73H	IGR-1	skin	COSMIC	DEETGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222
p.P409S	SIDM00333	Endometrial Carcinoma	GDSC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0556
p.P409S	MFE-319	endometrium	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.0556
p.V223A	SIDM00217	Colorectal Carcinoma	GDSC	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.1389
p.V223A	SIDM00217	Colorectal Carcinoma	GDSC	DNYHFYSSIP	CBL_PTK	224:233	Mutation rewiring degron network	0.3056
p.V223A	SNU-1040	large intestine	COSMIC	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.1389
p.V223A	SNU-1040	large intestine	COSMIC	DNYHFYSSIP	CBL_PTK	224:233	Mutation rewiring degron network	0.3056
p.R25G	SIDM00217	Colorectal Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.3056
p.R25G	SNU-1040	large intestine	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.3056
p.I22V	SIDM01018	Hodgkin's Lymphoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2222
p.I22V	KM-H2	haematopoietic and lymphoid tissue	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation rewiring degron network	0.2222
p.D29V	SIDM00381	Cervical Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7785
p.D29V	SKG-IIIa	cervix	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.7785
p.P386S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.P386S	MFE-319	endometrium	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation rewiring degron network	0.1389
p.H222R	ACH-000990	Endometrial/Uterine Cancer	CCLE	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.1667
p.H222R	ACH-000990	Endometrial/Uterine Cancer	CCLE	DNYHFYSSIP	CBL_PTK	224:233	Mutation rewiring degron network	0.2778
p.V200A	ACH-000999	Colon/Colorectal Cancer	CCLE	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.0833
p.V200A	SNU-1040	large intestine	COSMIC	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.0833
p.H222Y	ACH-001863	Bile Duct Cancer	CCLE	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.1667
p.H222Y	ACH-001863	Bile Duct Cancer	CCLE	DNYHFYSSIP	CBL_PTK	224:233	Mutation rewiring degron network	0.2778
p.S398N	SNU-81	large intestine	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.7069
p.R433H	no-10	central nervous system	COSMIC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	421:428	Mutation blocking phosphorylation signal	0.6389
p.D29E	H2369	pleura	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	26:32	Mutation altering degron motif	0.6758
p.P393S	MFE-319	endometrium	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	393:399	Mutation altering degron motif	0.6752
p.V207A	SNU-1040	large intestine	COSMIC	ETTMVPSP	DEG_COP1_1	209:216	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFE2L2

UniProt ID: Q16236

Entrez ID: 4780

Protein name: Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFE2L2 in