DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DNYHFYSSIP
Uniprot ID:
Q16236
Source protein:
Nuclear factor erythroid 2-related factor 2
Source gene:
NFE2L2
Class:
CBL_PTK
Location:
224:233
E3 ligase:
CBL
DEGRON score:
0.9977
ASA_SCORE:
65.74
COIL:
0.8049
CONS_SCORE:
0.4921
DSS_SCORE:
0.309
HELIX:
0.1226
FCONS_SCORE:
1.0891
RIG_SCORE:
0.7964
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M235I
TCGA-63-A5MY
LUSC
TCGA
DNYHFYSSIP
CBL_PTK
0.2778
p.L243F
DO49976
CESC
ICGC
DNYHFYSSIP
CBL_PTK
0.5
p.L243F
DO231152
LUSC
ICGC
DNYHFYSSIP
CBL_PTK
0.5
p.D239E
DO14166
HNSC
ICGC
DNYHFYSSIP
CBL_PTK
0.1667
p.S232R
DO229045
LICA
ICGC
DNYHFYSSIP
CBL_PTK
0.7427
p.S233G
DO51407
PRAD
ICGC
DNYHFYSSIP
CBL_PTK
0.6993
p.P233S
SIDM01259
B-Lymphoblastic Leukemia
GDSC
DNYHFYSSIP
CBL_PTK
0.6752
p.P233S
SIDM00267
Biliary Tract Carcinoma
GDSC
DNYHFYSSIP
CBL_PTK
0.6752
p.P233S
SIDM00060
Ovarian Carcinoma
GDSC
DNYHFYSSIP
CBL_PTK
0.6752
p.V223A
SIDM00217
Colorectal Carcinoma
GDSC
DNYHFYSSIP
CBL_PTK
0.3056
p.V223A
SNU-1040
large_intestine
COSMIC
DNYHFYSSIP
CBL_PTK
0.3056
p.H222R
ACH-000990
Endometrial/Uterine Cancer
CCLE
DNYHFYSSIP
CBL_PTK
0.2778
p.H222Y
ACH-001863
Bile Duct Cancer
CCLE
DNYHFYSSIP
CBL_PTK
0.2778
Drug responses associated with NFE2L2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DNYHFYSSIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16236
Nuclear factor erythroid 2-related factor 2
CBL_PTK
224:233
DNYHFYSSIP
CBL
0.9977
More...
