DegronMD

Uniprot ID: Q16236

Source protein: Nuclear factor erythroid 2-related factor 2

Source gene: NFE2L2

Class: DEG_Kelch_Keap1_2

Location: 26:32

E3 ligase: KEAP1

DEGRON score: 0.9396

ASA_SCORE: 31.0143

COIL: 0.7017

CONS_SCORE: 0.7106

DSS_SCORE: 0.1124

HELIX: 0.1173

FCONS_SCORE: 1.389

RIG_SCORE: 0.8333

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D27H	TCGA-17-Z026	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D27H	TCGA-34-2608	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.Q26R	TCGA-17-Z033	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7329
p.Q26R	TCGA-33-A4WN	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7329
p.R34G	TCGA-18-3411	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-63-A5ML	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-77-6843	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-85-8049	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-94-7943	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-A5-A0R8	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-AJ-A5DV	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-AJ-A8CV	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-AX-A05W	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-B5-A0JT	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-CR-7383	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-DK-AA6Q	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-E5-A2PC	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-EY-A1H0	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-FI-A2D4	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-G2-A3IB	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-GU-AATQ	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-LN-A49R	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-NC-A5HR	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	TCGA-XF-AAN3	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	SIDM00182	Head and Neck Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34G	LB771-HNC	upper_aerodigestive_tract	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.G31A	TCGA-18-3415	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	TCGA-22-5483	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	TCGA-66-2766	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	TCGA-68-A59J	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	TCGA-85-A4CL	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	TCGA-DK-A1AE	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	TCGA-LN-A7HW	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	SIDM00820	Kidney Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	RCC-ER	kidney	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.G31A	NCI-H2228	lung	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.754
p.R34Q	TCGA-18-4721	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34Q	TCGA-22-5477	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34Q	TCGA-66-2795	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34Q	TCGA-96-7545	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34Q	TCGA-AX-A2HC	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34Q	TCGA-JW-A852	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34Q	TCGA-LA-A446	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34Q	ACH-000690	Lung Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.D29H	TCGA-21-1075	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-22-4605	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-34-5240	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-46-3768	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-78-8660	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-92-7341	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-B5-A11R	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-C5-A1MN	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-CV-6951	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-CV-7424	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-CZ-5456	KIRC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-DS-A0VM	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-P3-A6T4	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-VR-A8ER	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-XF-A9SY	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	TCGA-YC-A9TC	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	SIDM01520	Oral Cavity Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.D29H	RERF-LC-Sq1	lung	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.7688
p.Q26P	TCGA-22-5473	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7035
p.Q26P	TCGA-DD-A4NI	LIHC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7035
p.Q26P	SIDM00506	Small Cell Lung Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7035
p.Q26P	COR-L88	lung	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.7035
p.R34P	TCGA-22-5479	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34P	TCGA-33-A5GW	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34P	TCGA-34-5236	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34P	TCGA-68-7755	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34P	TCGA-98-A53I	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34P	TCGA-CN-4723	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34P	TCGA-K4-A5RI	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.R34P	SIDM01612	Endometrial Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.D29Y	TCGA-33-4586	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7325
p.D29Y	TCGA-63-A5MJ	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7325
p.D29Y	TCGA-FD-A3N6	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7325
p.D29Y	TCGA-IQ-A61H	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7325
p.D29Y	TCGA-JX-A3Q0	CESC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7325
p.D29N	TCGA-33-4589	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6932
p.D29N	TCGA-33-AAS8	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6932
p.D29N	TCGA-56-8629	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6932
p.D29N	TCGA-58-A46K	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6932
p.D29N	TCGA-66-2783	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6932
p.D29G	TCGA-34-2596	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7198
p.D29G	TCGA-52-7812	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7198
p.D29G	TCGA-62-8395	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7198
p.D29G	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7198
p.D29G	TE-11	oesophagus	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.7198
p.W24C	TCGA-34-2608	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.W24C	TCGA-56-7582	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.W24C	TCGA-CV-6935	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.W24C	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.W24C	KYSE-70	oesophagus	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.Q26L	TCGA-37-4135	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7765
p.L30F	TCGA-46-3765	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6981
p.L30F	TCGA-51-4081	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6981
p.L30F	TCGA-68-7756	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6981
p.L30F	TCGA-77-A5GF	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6981
p.L30F	TCGA-H7-7774	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6981
p.L30F	TCGA-IG-A625	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6981
p.R34L	TCGA-52-7812	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.G31R	TCGA-55-A48Y	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7568
p.G31R	TCGA-BT-A20U	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7568
p.G31R	SIDM00596	Endometrial Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7568
p.G31R	HEC-1	endometrium	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.7568
p.G31V	TCGA-63-A5MB	LUSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7532
p.W24R	TCGA-93-8067	LUAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.W24R	TCGA-BT-A0YX	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.W24R	TCGA-CQ-A4CG	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.W24R	TCGA-L5-A88Z	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.Q26K	TCGA-A5-A0GW	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6944
p.F39S	TCGA-AX-A06F	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.1389
p.D16Y	TCGA-AX-A2HC	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.0556
p.D38V	TCGA-B5-A3FC	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.1667
p.L30H	TCGA-BP-5178	KIRC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7313
p.L30H	TCGA-CQ-5324	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7313
p.L30R	TCGA-BQ-5881	KIRP	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.8428
p.V32G	TCGA-CN-6019	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7532
p.I28T	TCGA-CV-7437	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.5966
p.I28T	TCGA-FZ-5924	PAAD	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.5966
p.D27Y	TCGA-DD-AAEH	LIHC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7325
p.D27N	TCGA-DF-A2KN	UCEC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.6932
p.G31E	TCGA-LN-A9FQ	ESCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7199
p.L30P	TCGA-MT-A67A	HNSC	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.7582
p.E35D	TCGA-YC-A89H	BLCA	TCGA	QDIDLGV	DEG_Kelch_Keap1_2	0.25
p.E19D	DO51948	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1389
p.R18G	DO51896	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO219053	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO219005	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO512	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO702	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO15366	HNSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO23482	LINC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO230982	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO224613	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO231179	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO26890	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO26475	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO26758	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO219151	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO27588	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO219203	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO232037	ORCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO219766	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO219765	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO40802	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO40966	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO43170	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO43114	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	DO42584	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	ACH-002265	Head and Neck Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18G	LB771-HNC	upper_aerodigestive_tract	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO219029	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO223009	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO222607	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO14830	HNSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO230535	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO230538	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO26512	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO26572	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO26778	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO27287	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO219122	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	DO219182	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18P	ACH-000946	Endometrial/Uterine Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.K37Q	DO219085	BLCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1944
p.K37Q	DO41752	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1944
p.R18Q	DO49978	CESC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO222645	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO230536	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO224541	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO26894	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO26492	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO26710	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO45450	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO27104	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	DO41572	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18Q	ACH-000593	Bladder Cancer	CCLE	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.E29K	DO227844	COCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.7022
p.S24N	DO222607	ESCA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.2778
p.V16G	DO14316	HNSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.0556
p.V16G	DO229033	LICA	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.0556
p.S17R	DO23482	LINC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.0833
p.R18L	DO224626	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R18L	DO27067	LUSC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.1111
p.R27G	DO41002	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.7568
p.F23S	DO41752	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.25
p.D22V	DO41871	UCEC	ICGC	QDIDLGV	DEG_Kelch_Keap1_2	0.2222
p.D27A	SIDM00188	Kidney Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7793
p.D27A	HA7-RCC	kidney	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.7793
p.R25G	SIDM00217	Colorectal Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.3056
p.R25G	SNU-1040	large_intestine	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.3056
p.I22V	SIDM01018	Hodgkin's Lymphoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.2222
p.I22V	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.2222
p.D29V	SIDM00381	Cervical Carcinoma	GDSC	QDIDLGV	DEG_Kelch_Keap1_2	0.7785
p.D29V	SKG-IIIa	cervix	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.7785
p.D29E	H2369	pleura	COSMIC	QDIDLGV	DEG_Kelch_Keap1_2	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QDIDLGV

Degron related mutations and impact score

Drug responses associated with NFE2L2 mutations

All proteins holding degron of QDIDLGV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_Kelch_Keap1_2	26:32	QDIDLGV	KEAP1	0.9396	More...