DegronMD

Uniprot ID: Q16236

Source protein: Nuclear factor erythroid 2-related factor 2

Source gene: NFE2L2

Class: DEG_COP1_1

Location: 209:216

E3 ligase: COP1

DEGRON score: 0.9951

ASA_SCORE: 72.35

COIL: 0.8099

CONS_SCORE: 0.4737

DSS_SCORE: 0.3918

HELIX: 0.1089

FCONS_SCORE: 0.9993

RIG_SCORE: 0.779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P214Q	TCGA-CG-5722	STAD	TCGA	ETTMVPSP	DEG_COP1_1	0.7035
p.D201H	DO224793	BRCA	ICGC	ETTMVPSP	DEG_COP1_1	0.1111
p.S207L	DO231179	LUSC	ICGC	ETTMVPSP	DEG_COP1_1	0.2778
p.M212I	DO219171	LUSC	ICGC	ETTMVPSP	DEG_COP1_1	0.6507
p.V223A	SIDM00217	Colorectal Carcinoma	GDSC	ETTMVPSP	DEG_COP1_1	0.1389
p.V223A	SNU-1040	large_intestine	COSMIC	ETTMVPSP	DEG_COP1_1	0.1389
p.H222R	ACH-000990	Endometrial/Uterine Cancer	CCLE	ETTMVPSP	DEG_COP1_1	0.1667
p.V200A	ACH-000999	Colon/Colorectal Cancer	CCLE	ETTMVPSP	DEG_COP1_1	0.0833
p.V200A	SNU-1040	large_intestine	COSMIC	ETTMVPSP	DEG_COP1_1	0.0833
p.H222Y	ACH-001863	Bile Duct Cancer	CCLE	ETTMVPSP	DEG_COP1_1	0.1667
p.V207A	SNU-1040	large_intestine	COSMIC	ETTMVPSP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_COP1_1	209:216	ETTMVPSP	COP1	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons