DegronMD

Uniprot ID: Q16236

Source protein: Nuclear factor erythroid 2-related factor 2

Source gene: NFE2L2

Class: DEG_SCF_FBW7_1

Location: 393:399

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 78.8857

COIL: 0.8597

CONS_SCORE: 0.5006

DSS_SCORE: 0.7561

HELIX: 0.0341

FCONS_SCORE: 0.9984

RIG_SCORE: 0.5868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A384V	TCGA-62-A471	LUAD	TCGA	PKTPVHS	DEG_SCF_FBW7_1	0.0833
p.G401V	TCGA-DA-A1IB	SKCM	TCGA	PKTPVHS	DEG_SCF_FBW7_1	0.2778
p.P406L	TCGA-EE-A3J5	SKCM	TCGA	PKTPVHS	DEG_SCF_FBW7_1	0.1389
p.V394M	DO219043	BLCA	ICGC	PKTPVHS	DEG_SCF_FBW7_1	0.7208
p.P386Q	DO229028	LICA	ICGC	PKTPVHS	DEG_SCF_FBW7_1	0.1389
p.P386T	DO229028	LICA	ICGC	PKTPVHS	DEG_SCF_FBW7_1	0.1389
p.S391N	DO25189	LUAD	ICGC	PKTPVHS	DEG_SCF_FBW7_1	0.2778
p.S391N	ACH-000991	Colon/Colorectal Cancer	CCLE	PKTPVHS	DEG_SCF_FBW7_1	0.2778
p.S391N	SNU-81	large_intestine	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	0.2778
p.P383L	DO47331	SKCM	ICGC	PKTPVHS	DEG_SCF_FBW7_1	0.0556
p.P409S	SIDM00333	Endometrial Carcinoma	GDSC	PKTPVHS	DEG_SCF_FBW7_1	0.0556
p.P409S	MFE-319	endometrium	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	0.0556
p.P386S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PKTPVHS	DEG_SCF_FBW7_1	0.1389
p.P386S	MFE-319	endometrium	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	0.1389
p.S398N	SNU-81	large_intestine	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	0.7069
p.P393S	MFE-319	endometrium	COSMIC	PKTPVHS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SCF_FBW7_1	393:399	PKTPVHS	FBXW7	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons