DegronMD

Uniprot ID: Q16236

Source protein: Nuclear factor erythroid 2-related factor 2

Source gene: NFE2L2

Class: DEG_SCF_SKP2-CKS1_1

Location: 421:428

E3 ligase: SKP2,CSK1

DEGRON score: 0.8791

ASA_SCORE: 105.6875

COIL: 0.8964

CONS_SCORE: 0.4634

DSS_SCORE: 0.7335

HELIX: 0.0824

FCONS_SCORE: 0.9927

RIG_SCORE: 0.6429

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G412V	TCGA-17-Z015	LUAD	TCGA	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S414N	TCGA-50-5930	LUAD	TCGA	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S414N	SIDM00193	Colorectal Carcinoma	GDSC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S414N	SNU-81	large_intestine	COSMIC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.V417M	TCGA-UY-A9PE	BLCA	TCGA	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T416P	DO227745	COCA	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D421N	DO229016	COCA	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.6932
p.R433T	DO49998	HNSC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.6389
p.D434G	DO219080	HNSC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.T419K	DO228974	LICA	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A429T	DO222381	STAD	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.3056
p.R426H	DO40889	UCEC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.8244
p.R426H	no-10	central_nervous_system	COSMIC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.8244
p.S425I	DO42568	UCEC	ICGC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.7341
p.R433H	no-10	central_nervous_system	COSMIC	QCENTPEK	DEG_SCF_SKP2-CKS1_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SCF_SKP2-CKS1_1	421:428	QCENTPEK	SKP2,CSK1	0.8791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons