DegronMD

Uniprot ID: Q16236

Source protein: Nuclear factor erythroid 2-related factor 2

Source gene: NFE2L2

Class: DEG_Kelch_Keap1_1

Location: 77:82

E3 ligase: KEAP1

DEGRON score: 0.9862

ASA_SCORE: 89.3

COIL: 0.9107

CONS_SCORE: 0.7079

DSS_SCORE: 0.4749

HELIX: 0.0307

FCONS_SCORE: 1.4561

RIG_SCORE: 0.7554

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D77G	TCGA-18-5592	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7198
p.T80K	TCGA-21-1071	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7306
p.T80K	TCGA-56-A4BY	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7306
p.T80K	TCGA-B1-A47M	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7306
p.E79Q	TCGA-22-5474	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-39-5022	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-56-5897	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-66-2770	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-85-7696	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-85-8052	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-94-A5I6	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-CV-6940	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-CV-7177	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-FD-A3SM	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-H7-7774	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-LN-A4MR	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-LN-A7HZ	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E79Q	TCGA-ZJ-AAXJ	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E82D	TCGA-4A-A93X	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-55-6975	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-A5-A0G9	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-B2-4098	KIRC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-BG-A0MK	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-BK-A0C9	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-BS-A0U7	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-D1-A1O7	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-DD-A39V	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-DS-A0VK	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-EY-A1H0	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-FD-A3SM	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-VS-A8EH	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	TCGA-ZH-A8Y2	CHOL	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	SIDM00591	Oral Cavity Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.E82D	HO-1-u-1	upper_aerodigestive_tract	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.6758
p.G81V	TCGA-51-4079	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7532
p.G81V	TCGA-BG-A0M4	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7532
p.G81V	TCGA-BQ-7051	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7532
p.G81V	TCGA-LN-A4MQ	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7532
p.T80A	TCGA-52-7622	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7139
p.T80A	TCGA-UF-A71B	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7139
p.T80I	TCGA-5R-AAAM	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7078
p.T80I	TCGA-FD-A5BU	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7078
p.T80I	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7078
p.T80I	KYSE-520	oesophagus	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7078
p.G81S	TCGA-60-2709	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	TCGA-66-2787	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	TCGA-EO-A22T	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	TCGA-LN-A8I0	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	TCGA-QS-A5YR	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	SIDM00174	Head and Neck Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	SIDM01624	Bladder Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	SIDM01529	Bladder Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	BB49-HNC	upper_aerodigestive_tract	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.G81S	OE21	oesophagus	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.E67K	TCGA-73-4658	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.0556
p.E79D	TCGA-92-8064	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.5647
p.E79D	TCGA-IR-A3LH	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.5647
p.E79D	DO48751	LIRI	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.5647
p.E79G	TCGA-92-8064	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7199
p.E79G	TCGA-IG-A50L	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7199
p.E79V	TCGA-97-7941	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7693
p.E79V	TCGA-DD-A4NO	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7693
p.E82Q	TCGA-97-8174	LUAD	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.E82Q	TCGA-Q1-A5R2	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.6744
p.T80P	TCGA-A5-A0GP	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7031
p.T80P	TCGA-BK-A0C9	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7031
p.G81D	TCGA-A7-A26E	BRCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7198
p.G81D	TCGA-B0-5097	KIRC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7198
p.G81C	TCGA-AJ-A2QO	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.76
p.G81C	TCGA-CV-7429	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.76
p.G81C	TCGA-DD-AADJ	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.76
p.E79K	TCGA-BL-A13I	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	TCGA-BT-A42B	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	TCGA-CV-6955	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	TCGA-CV-7099	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	TCGA-HG-A2PA	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	TCGA-IG-A8O2	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	TCGA-J1-A4AH	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	TCGA-P3-A5QF	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	SIDM00625	Other Sarcomas	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	MES-SA	soft_tissue	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E79K	LK-2	lung	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7022
p.E82G	TCGA-BQ-7044	KIRP	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7199
p.E82G	TCGA-DD-AAC8	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7199
p.E82G	TCGA-LN-A8HZ	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7199
p.T80R	TCGA-D1-A17U	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7876
p.T80R	SIDM00935	Other Solid Cancers	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7876
p.T80R	CAL-39	vulva	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7876
p.G81R	TCGA-DD-AAVY	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7568
p.D77Y	TCGA-DS-A3LQ	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7325
p.D77Y	TCGA-L3-A524	LUSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7325
p.D77Y	SIDM01248	Thyroid Gland Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7325
p.D77Y	SIDM01162	Kidney Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7325
p.D77Y	SIDM01167	Thyroid Gland Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7325
p.D77Y	CGTH-W-1	thyroid	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7325
p.D77Y	SW156	kidney	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7325
p.D77H	TCGA-EK-A2PI	CESC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7688
p.E67D	TCGA-EO-A22U	UCEC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.0556
p.E82V	TCGA-FD-A43Y	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7693
p.E82V	TCGA-T3-A92N	HNSC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7693
p.G81A	TCGA-G2-AA3C	BLCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.754
p.G81A	TCGA-G3-AAV3	LIHC	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.754
p.E82A	TCGA-LN-A8I1	ESCA	TCGA	DEETGE	DEG_Kelch_Keap1_1	0.7701
p.S81G	DO52615	BOCA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.6993
p.A90T	DO233784	GACA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.1111
p.A84D	DO229031	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.2778
p.I70L	DO44848	LICA	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.1389
p.H91R	DO26436	LUSC	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.0833
p.H91N	DO37405	SKCM	ICGC	DEETGE	DEG_Kelch_Keap1_1	0.0833
p.D77V	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7785
p.D77V	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.7785
p.D77V	KYSE-180	oesophagus	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7785
p.D77V	EBC-1	lung	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.7785
p.Q73H	SIDM01060	Melanoma	GDSC	DEETGE	DEG_Kelch_Keap1_1	0.2222
p.Q73H	IGR-1	skin	COSMIC	DEETGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_Kelch_Keap1_1	77:82	DEETGE	KEAP1	0.9862	More...
Q86YC2	Partner and localizer of BRCA2	DEG_Kelch_Keap1_1	89:94	DEETGE	KEAP1	0.9881	More...
Q96SB3	Neurabin-2	DEG_Kelch_Keap1_1	620:625	DEETGE	KEAP1	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DEETGE

Degron related mutations and impact score

Drug responses associated with NFE2L2 mutations

All proteins holding degron of DEETGE